European consensus conference on faecal microbiota transplantation in clinical practice
Giovanni Cammarota,Gianluca Ianiro,Herbert Tilg,Mirjana Rajilić-Stojanović,Patrizia Kump,Reetta Satokari,Harry Sokol,Perttu Arkkila,Cristina Pintus,Ailsa Hart,Jonathan Segal,Marina Aloi,Luca Masucci,Antonio Molinaro,Franco Scaldaferri,Giovanni Gasbarrini,Antonio López-Sanromán,Alexander Link,Pieter F. de Groot,Willem M. de Vos,Willem M. de Vos,Christoph Högenauer,Peter Malfertheiner,Eero Mattila,Tomica Milosavljevic,Max Nieuwdorp,Max Nieuwdorp,Maurizio Sanguinetti,Magnus Simren,Antonio Gasbarrini +29 more
TLDR
This consensus report strongly recommends the implementation of FMT centres for the treatment of C. difficile infection as well as traces the guidelines of technicality, regulatory, administrative and laboratory requirements.Abstract:
Faecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium difficile infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Although the health community is assessing FMT with renewed interest and patients are becoming more aware, there are technical and logistical issues in establishing such a non-standardised treatment into the clinical practice with safety and proper governance. In view of this, an evidence-based recommendation is needed to drive the practical implementation of FMT. In this European Consensus Conference, 28 experts from 10 countries collaborated, in separate working groups and through an evidence-based process, to provide statements on the following key issues: FMT indications; donor selection; preparation of faecal material; clinical management and faecal delivery and basic requirements for implementing an FMT centre. Statements developed by each working group were evaluated and voted by all members, first through an electronic Delphi process, and then in a plenary consensus conference. The recommendations were released according to best available evidence, in order to act as guidance for physicians who plan to implement FMT, aiming at supporting the broad availability of the procedure, discussing other issues relevant to FMT and promoting future clinical research in the area of gut microbiota manipulation. This consensus report strongly recommends the implementation of FMT centres for the treatment of C. difficile infection as well as traces the guidelines of technicality, regulatory, administrative and laboratory requirements.read more
Citations
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The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
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Role of the gut microbiota in nutrition and health
TL;DR: Ana M Valdes and colleagues discuss strategies for modulating the gut microbiota through diet and probiotics and suggest that a Mediterranean diet supplemented with probiotics can be a viable alternative to a probiotic regime.
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Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients
Erez N. Baruch,Erez N. Baruch,Ilan Youngster,Guy Ben-Betzalel,Rona Ortenberg,Adi Lahat,Lior H. Katz,Katerina Adler,Daniela Dick-Necula,Stephen P. Raskin,Stephen P. Raskin,Naamah Bloch,Daniil Rotin,Liat Anafi,Camila Avivi,Jenny Melnichenko,Yael Steinberg-Silman,Ronac Mamtani,Hagit Harati,Nethanel Asher,Ronnie Shapira-Frommer,Tal Brosh-Nissimov,Yael Eshet,Yael Eshet,Shira Ben-Simon,Oren Ziv,Abdul Wadud Khan,Moran Amit,Nadim J. Ajami,Iris Barshack,Iris Barshack,Jacob Schachter,Jacob Schachter,Jennifer A. Wargo,Omry Koren,Gal Markel,Gal Markel,Ben Boursi,Ben Boursi,Ben Boursi +39 more
TL;DR: Treatment with FMT was associated with favorable changes in immune cell infiltrates and gene expression profiles in both the gut lamina propria and the tumor microenvironment, which have implications for modulating the gut microbiota in cancer treatment.
Journal ArticleDOI
Gut Microbiome: Profound Implications for Diet and Disease
Ronald D. Hills,Benjamin Pontefract,Hillary R. Mishcon,Cody Black,Cody Black,Steven C. Sutton,Cory R. Theberge +6 more
TL;DR: The role of diet quality, carbohydrate intake, fermentable FODMAPs, and prebiotic fiber in maintaining healthy gut flora is reviewed and the implications are discussed for various conditions including obesity, diabetes, irritable bowel syndrome, inflammatory bowel disease, depression, and cardiovascular disease.
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The global preclinical antibacterial pipeline.
TL;DR: The innovative potential of the preclinical pipeline compared with the clinical pipeline is encouraging but fragile and much more work, focus and funding are needed for the novel approaches to result in effective antibacterial therapies to sustainably combat antibacterial resistance.
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