Journal ArticleDOI
Exosomes as biomarker treasure chests for prostate cancer.
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TLDR
This narrative review describes recent progress in exosome research, focusing on the potential role of exosomes as novel biomarkers for prostate cancer (PCa), to acquaint clinicians and researchers in the field of urology with the potential roles of exOSomes as biomarker treasure chests and with their clinical value.About:
This article is published in European Urology.The article was published on 2011-05-01. It has received 269 citations till now. The article focuses on the topics: Exosome & Microvesicle.read more
Citations
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Journal ArticleDOI
Quantitative and stoichiometric analysis of the microRNA content of exosomes.
John R. Chevillet,Qing Kang,Ingrid K. Ruf,Hilary A. Briggs,Lucia Vojtech,Sean M. Hughes,Heather H. Cheng,Jason D. Arroyo,Emily K. Meredith,Emily N. Gallichotte,Era L. Pogosova-Agadjanyan,Colm Morrissey,Derek L. Stirewalt,Florian Hladik,Evan Y. Yu,Celestia S. Higano,Muneesh Tewari +16 more
TL;DR: It is shown here that most exosomes derived from standard preparations do not harbor many copies of miRNA molecules, and are, therefore, individually unlikely to be functional as vehicles for miRNA-based communication.
Journal ArticleDOI
Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy
TL;DR: Extracellular vesicles are emerging as potent genetic information transfer agents underpinning a range of biological processes and with therapeutic potential.
Journal ArticleDOI
Molecular lipidomics of exosomes released by PC-3 prostate cancer cells.
Alicia Llorente,Tore Skotland,Tore Skotland,Tuulia Sylvänne,Dimple Kauhanen,Tomasz Róg,Adam Orłowski,Ilpo Vattulainen,Ilpo Vattulainen,Kim Ekroos,Kirsten Sandvig,Kirsten Sandvig +11 more
TL;DR: The detailed lipid composition provided in this study may be useful to understand the mechanism of exosome formation, release and function, and several of the lipids enriched in exosomes could potentially be used as cancer biomarkers.
Journal ArticleDOI
How pure are your vesicles
Jason P. Webber,Aled Clayton +1 more
TL;DR: A straightforward method to estimate the purity of vesicle preparations by comparing the ratio of nano-vesicle counts to protein concentration, using tools such as the increasingly available NanoSight platform and a colorimetric protein assaysuch as the BCA-assay is proposed.
Journal ArticleDOI
Beyond PSA: The Next Generation of Prostate Cancer Biomarkers
TL;DR: The current state of prostate cancer biomarker research, including the PSA revolution, its impact on early cancer detection, the recent advances in biomarker discovery, and the future efforts that promise to improve clinical management of this disease are reviewed.
References
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Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial
Bernard Escudier,Thierry Dorval,Nathalie Chaput,Fabrice Andre,Marie-Pierre Caby,Sophie Novault,Caroline Flament,Christophe Leboulaire,Christophe Borg,Sebastian Amigorena,Catherine Boccaccio,Christian Bonnerot,Olivier Dhellin,Mojgan Movassagh,Sophie Piperno,Caroline Robert,Vincent Serra,Nancy Valente,Jean-Bernard Le Pecq,Alain Spatz,Olivier Lantz,Thomas Tursz,Eric Angevin,Laurence Zitvogel +23 more
TL;DR: The first exosome Phase I trial highlighted the feasibility of large scale exosomal MHC class II molecules production and the safety of exosomes administration.
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Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73.
Clotilde Théry,Armelle Regnault,Jérôme Garin,Joseph Wolfers,Laurence Zitvogel,Paola Ricciardi-Castagnoli,Graça Raposo,Sebastian Amigorena +7 more
TL;DR: DC-derived exosomes accumulate a defined subset of cellular proteins reflecting their endosomal biogenesis and accounting for their biological function, and exosome production is downregulated upon DC maturation, indicating that in vivo,Exosomes are produced by immature DCs in peripheral tissues.
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Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells.
Adrian E. Morelli,Adriana T. Larregina,William J. Shufesky,Mara Sullivan,Donna B. Stolz,Glenn D. Papworth,Alan F. Zahorchak,Alison J. Logar,Zhiliang Wang,Simon C. Watkins,Louis D. Falo,Angus W. Thomson +11 more
TL;DR: It is demonstrated that exosomes also are internalized and processed by immature DCs for presentation to CD4(+) T cells, implying that exOSomes present in circulation or extracellular fluids constitute an alternative source of self- or allopeptides for DCs during maintenance of peripheral tolerance or initiation of the indirect pathway of allorecognition in transplantation.
Journal ArticleDOI
Malignant effusions and immunogenic tumour-derived exosomes
Fabrice Andre,Noël E. C. Schartz,Mojgan Movassagh,Caroline Flament,Patricia Pautier,Philippe Morice,Christophe Pomel,Catherine Lhommé,Bernard Escudier,Thierry Le Chevalier,Thomas Tursz,Sebastian Amigorena,Graça Raposo,Eric Angevin,Laurence Zitvogel +14 more
TL;DR: Exosomes from patients with melanoma deliver Mart1 tumour antigens to dendritic cells derived from monocytes for cross presentation to clones of cytotoxic T lymphocytes specific to Mart1, opening up new avenues for immunisation against cancers.