Journal ArticleDOI
Global Cancer Incidence and Mortality Rates and Trends—An Update
Reads0
Chats0
TLDR
Applied cancer control measures are needed to reduce rates in HICs and arrest the growing burden in LMICs, as well as for lung, colorectal, breast, and prostate cancer, although some low- and middle-income countries (LMIC) now count among those with the highest rates.Abstract:
There are limited published data on recent cancer incidence and mortality trends worldwide. We used the International Agency for Research on Cancer's CANCERMondial clearinghouse to present age-standardized cancer incidence and death rates for 2003-2007. We also present trends in incidence through 2007 and mortality through 2012 for select countries from five continents. High-income countries (HIC) continue to have the highest incidence rates for all sites, as well as for lung, colorectal, breast, and prostate cancer, although some low- and middle-income countries (LMIC) now count among those with the highest rates. Mortality rates from these cancers are declining in many HICs while they are increasing in LMICs. LMICs have the highest rates of stomach, liver, esophageal, and cervical cancer. Although rates remain high in HICs, they are plateauing or decreasing for the most common cancers due to decreases in known risk factors, screening and early detection, and improved treatment (mortality only). In contrast, rates in several LMICs are increasing for these cancers due to increases in smoking, excess body weight, and physical inactivity. LMICs also have a disproportionate burden of infection-related cancers. Applied cancer control measures are needed to reduce rates in HICs and arrest the growing burden in LMICs.read more
Citations
More filters
Journal ArticleDOI
Comparing the clinical efficacy of abiraterone acetate, enzalutamide, and orteronel in patients with metastatic castration-resistant prostate cancer by performing a network meta-analysis of eight randomized controlled trials
TL;DR: A network meta-analysis of randomized controlled trials for men with mCRPC treated with one of the AR targeting agents can help to guide treatment selection, especially because AR-targeted agents have not been compared directly in head-to-head trials.
Journal ArticleDOI
Lower Education and Household Income Contribute to Advanced Disease, Less Treatment Received and Poorer Prognosis in Patients with Hepatocellular Carcinoma.
TL;DR: Education and income are critically associated with early diagnosis, treatments and prognosis of HCC and much more efforts should be taken to support the patients with less education and lower income to improve the outcomes of H CC.
Journal ArticleDOI
Osimertinib in untreated epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer.
TL;DR: This data indicates that non-small cell lung cancer accounts for approximately 80–85% of all cases of lung cancer and is commonly diagnosed at an advanced stage of disease.
Journal ArticleDOI
Bisdemethoxycurcumin Enhances the Sensitivity of Non-small Cell Lung Cancer Cells to Icotinib via Dual Induction of Autophagy and Apoptosis.
Min Xiang,He Guo Jiang,Yang Shu,Yu Jiao Chen,Jun Jin,Yu Min Zhu,Mei Yu Li,Jian Nong Wu,Jian Li +8 more
TL;DR: The data indicate that BMDC has the potential to improve the treatment of primary EGFR-TKI resistant NISCLC that cannot be controlled with single-target agent, such as icotinib.
Journal ArticleDOI
Non-contact co-culture with human vascular endothelial cells promotes epithelial-to-mesenchymal transition of cervical cancer SiHa cells by activating the NOTCH1/LOX/SNAIL pathway.
TL;DR: Co-culture with human umbilical vein endothelial cells promoted the epithelial-to-mesenchymal transition of Si Ha cells by activating the NOTCH1/LOX/SNAIL1 pathway in SiHa cells, which enhanced their invasive and metastatic capacities.
References
More filters
Journal ArticleDOI
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
Journal ArticleDOI
Reduced lung-cancer mortality with low-dose computed tomographic screening.
Denise R. Aberle,Amanda M. Adams,Christine D. Berg,William C. Black,Jonathan D. Clapp,Richard M. Fagerstrom,Ilana F. Gareen,Constantine Gatsonis,Pamela M. Marcus,JoRean D. Sicks +9 more
TL;DR: Screening with the use of low-dose CT reduces mortality from lung cancer, as compared with the radiography group, and the rate of death from any cause was reduced.
Journal ArticleDOI
The global health burden of infection-associated cancers in the year 2002.
TL;DR: The fraction of the different types of cancer, and of all cancers worldwide and in different regions, has been estimated using several methods; primarily by reviewing the evidence for the strength of the association (relative risk) and the prevalence of infection in different world areas.
GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Internet]
J Ferlay,I Soerjomataram,M Ervik,R Dikshit,S Eser,Colin Mathers,M Rebelo,D.M. Parkin,David Forman,Freddie Bray,S Elser,M Ervick,Donald Maxwell Parkin +12 more
Journal ArticleDOI
Changing patterns in the incidence of esophageal and gastric carcinoma in the United States
TL;DR: The authors update the incidence trends through 1994 and further consider the trends by age group.