Journal ArticleDOI
Global Cancer Incidence and Mortality Rates and Trends—An Update
Reads0
Chats0
TLDR
Applied cancer control measures are needed to reduce rates in HICs and arrest the growing burden in LMICs, as well as for lung, colorectal, breast, and prostate cancer, although some low- and middle-income countries (LMIC) now count among those with the highest rates.Abstract:
There are limited published data on recent cancer incidence and mortality trends worldwide. We used the International Agency for Research on Cancer's CANCERMondial clearinghouse to present age-standardized cancer incidence and death rates for 2003-2007. We also present trends in incidence through 2007 and mortality through 2012 for select countries from five continents. High-income countries (HIC) continue to have the highest incidence rates for all sites, as well as for lung, colorectal, breast, and prostate cancer, although some low- and middle-income countries (LMIC) now count among those with the highest rates. Mortality rates from these cancers are declining in many HICs while they are increasing in LMICs. LMICs have the highest rates of stomach, liver, esophageal, and cervical cancer. Although rates remain high in HICs, they are plateauing or decreasing for the most common cancers due to decreases in known risk factors, screening and early detection, and improved treatment (mortality only). In contrast, rates in several LMICs are increasing for these cancers due to increases in smoking, excess body weight, and physical inactivity. LMICs also have a disproportionate burden of infection-related cancers. Applied cancer control measures are needed to reduce rates in HICs and arrest the growing burden in LMICs.read more
Citations
More filters
Journal ArticleDOI
The Role of the Renin-Angiotensin System in the Cancer Stem Cell Niche.
TL;DR: Cancer stem cells (CSCs) drive metastasis, treatment resistance, and tumor recurrence as discussed by the authors, and they reside within a niche, an anatomically distinct site within the tumor microenvironment (TME).
Journal ArticleDOI
Clinical Implications of Augmenter of Liver Regeneration in Cancer: A Systematic Review.
TL;DR: ALR clearly plays a role in cancer biology and demonstrates potential as a therapeutic target and treatment of cells with exogenous ALR shows an anti-apoptotic effect while silencing or inhibiting ALR decreases cell and tumor survival.
Journal ArticleDOI
Shenqi Fuzheng Injection in the Treatment of Breast Cancer: A Meta-analysis of Randomized Controlled Trials.
TL;DR: The current evidence suggested that using SQFZI as an adjunct treatment to chemotherapy may be preferable for patients with breast cancer compared to chemotherapy alone.
Journal ArticleDOI
Obese Animals as Models for Numerous Diseases: Advantages and Applications.
TL;DR: In this article, a variety of animal models have been developed to investigate obesity pathogenesis, development, therapies and complications, and to represent models to study diseases and conditions that develop with obesity or where obesity represents a risk factor.
Journal ArticleDOI
miRNAs in Health and Disease: A Focus on the Breast Cancer Metastatic Cascade towards the Brain.
Marta Sereno,Mafalda Videira,Imola Wilhelm,István A. Krizbai,István A. Krizbai,Maria Alexandra Brito +5 more
TL;DR: This state-of-the-art review summarizes the current knowledge about miRNAs and illustrates their role as powerful regulators of physiological processes and highlights their aberrant expression in disease, including specific cancer types and the differential hosting-metastases preferences that influence several steps of tumorigenesis.
References
More filters
Journal ArticleDOI
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
Journal ArticleDOI
Reduced lung-cancer mortality with low-dose computed tomographic screening.
Denise R. Aberle,Amanda M. Adams,Christine D. Berg,William C. Black,Jonathan D. Clapp,Richard M. Fagerstrom,Ilana F. Gareen,Constantine Gatsonis,Pamela M. Marcus,JoRean D. Sicks +9 more
TL;DR: Screening with the use of low-dose CT reduces mortality from lung cancer, as compared with the radiography group, and the rate of death from any cause was reduced.
Journal ArticleDOI
The global health burden of infection-associated cancers in the year 2002.
TL;DR: The fraction of the different types of cancer, and of all cancers worldwide and in different regions, has been estimated using several methods; primarily by reviewing the evidence for the strength of the association (relative risk) and the prevalence of infection in different world areas.
GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Internet]
J Ferlay,I Soerjomataram,M Ervik,R Dikshit,S Eser,Colin Mathers,M Rebelo,D.M. Parkin,David Forman,Freddie Bray,S Elser,M Ervick,Donald Maxwell Parkin +12 more
Journal ArticleDOI
Changing patterns in the incidence of esophageal and gastric carcinoma in the United States
TL;DR: The authors update the incidence trends through 1994 and further consider the trends by age group.