Journal ArticleDOI
Global Cancer Incidence and Mortality Rates and Trends—An Update
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TLDR
Applied cancer control measures are needed to reduce rates in HICs and arrest the growing burden in LMICs, as well as for lung, colorectal, breast, and prostate cancer, although some low- and middle-income countries (LMIC) now count among those with the highest rates.Abstract:
There are limited published data on recent cancer incidence and mortality trends worldwide. We used the International Agency for Research on Cancer's CANCERMondial clearinghouse to present age-standardized cancer incidence and death rates for 2003-2007. We also present trends in incidence through 2007 and mortality through 2012 for select countries from five continents. High-income countries (HIC) continue to have the highest incidence rates for all sites, as well as for lung, colorectal, breast, and prostate cancer, although some low- and middle-income countries (LMIC) now count among those with the highest rates. Mortality rates from these cancers are declining in many HICs while they are increasing in LMICs. LMICs have the highest rates of stomach, liver, esophageal, and cervical cancer. Although rates remain high in HICs, they are plateauing or decreasing for the most common cancers due to decreases in known risk factors, screening and early detection, and improved treatment (mortality only). In contrast, rates in several LMICs are increasing for these cancers due to increases in smoking, excess body weight, and physical inactivity. LMICs also have a disproportionate burden of infection-related cancers. Applied cancer control measures are needed to reduce rates in HICs and arrest the growing burden in LMICs.read more
Citations
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Monomeric and dimeric coordinatively saturated and substitutionally inert Ru(ii) polypyridyl complexes as anticancer drug candidates.
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Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells.
Faezeh Ghasemi,Mojtaba Shafiee,Zarrin Banikazemi,Mohammad Hossein Pourhanifeh,Hashem Khanbabaei,Amir Shamshirian,Shirin Amiri Moghadam,Reza ArefNezhad,Amirhossein Sahebkar,Amir Avan,Hamed Mirzaei +10 more
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The Proteogenomic Landscape of Curable Prostate Cancer.
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Vaginal dysbiosis, and the risk of human papillomavirus and cervical cancer : systematic review and meta-analysis
Nele Brusselaers,Nele Brusselaers,Nele Brusselaers,Sadeep Shrestha,Janneke van de Wijgert,Hans Verstraelen +5 more
TL;DR: This study supports a causal link between vaginal dysbiosis and cervical cancer along the oncogenic human papillomavirus acquisition, persistence, and cervicovaginal dysplasia development pathway.
Journal ArticleDOI
The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma.
Jin-Lan Huang,Jin-Lan Huang,Shun-wang Cao,Qishui Ou,Bin Yang,Shi-hao Zheng,Jing Tang,Jing Chen,Yan-Wei Hu,Lei Zheng,Qian Wang +10 more
TL;DR: PTTG3P, a valuable marker of HCC prognosis, promotes tumor growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in HCC and might represent a potential target for gene-based therapy.
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