Journal ArticleDOI
Global Cancer Incidence and Mortality Rates and Trends—An Update
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TLDR
Applied cancer control measures are needed to reduce rates in HICs and arrest the growing burden in LMICs, as well as for lung, colorectal, breast, and prostate cancer, although some low- and middle-income countries (LMIC) now count among those with the highest rates.Abstract:
There are limited published data on recent cancer incidence and mortality trends worldwide. We used the International Agency for Research on Cancer's CANCERMondial clearinghouse to present age-standardized cancer incidence and death rates for 2003-2007. We also present trends in incidence through 2007 and mortality through 2012 for select countries from five continents. High-income countries (HIC) continue to have the highest incidence rates for all sites, as well as for lung, colorectal, breast, and prostate cancer, although some low- and middle-income countries (LMIC) now count among those with the highest rates. Mortality rates from these cancers are declining in many HICs while they are increasing in LMICs. LMICs have the highest rates of stomach, liver, esophageal, and cervical cancer. Although rates remain high in HICs, they are plateauing or decreasing for the most common cancers due to decreases in known risk factors, screening and early detection, and improved treatment (mortality only). In contrast, rates in several LMICs are increasing for these cancers due to increases in smoking, excess body weight, and physical inactivity. LMICs also have a disproportionate burden of infection-related cancers. Applied cancer control measures are needed to reduce rates in HICs and arrest the growing burden in LMICs.read more
Citations
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Racial/Ethnic Disparities in Cervical Cancer Screening and Outcomes
Laura W. Musselwhite,Cristina Mendes de Oliveira,Tendai Kwaramba,Naitielle de Paula Pantano,Jennifer S. Smith,José Humberto Tavares Guerreiro Fregnani,Rui Manuel Reis,Edmundo Carvalho Mauad,Fabiana de Lima Vazquez,Adhemar Longatto-Filho +9 more
TL;DR: An overview of the current literature on racial disparities in cervical cancer screening, incidence, treatment and outcome is provided to inform future strategies to reduce persistent inequities.
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HOTAIR, a long noncoding RNA, is a marker of abnormal cell cycle regulation in lung cancer.
Minghui Liu,Hongyi Zhang,Ying Li,Rui Wang,Yongwen Li,Hongbing Zhang,Dian Ren,Hongyu Liu,Chunsheng Kang,Jun Chen +9 more
TL;DR: It was shown that lncRNA HOTAIR is an optimal indicator of cell cycle dysregulation in lung cancer and was associated with resistance to gefitinib through the dysregulated cell cycle.
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KMT2C Mutations in Diffuse-Type Gastric Adenocarcinoma Promote Epithelial-to-Mesenchymal Transition
Soo-Jeong Cho,Chang Hwan Yoon,Jun Ho Lee,Kevin K. Chang,Jian Xian Lin,Young-Ho Kim,Myeong Cherl Kook,Bulent Arman Aksoy,Bulent Arman Aksoy,Do Joong Park,Do Joong Park,Hassan Ashktorab,Duane T. Smoot,Nikolaus Schultz,Sam S. Yoon +14 more
TL;DR: KMT2C loss in DGA promotes EMT and is associated with worse overall survival, and reversed CSC resistance to chemotherapy via promotion of DNA damage and apoptosis.
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Epigenetic IVD Tests for Personalized Precision Medicine in Cancer.
TL;DR: Current commercial epigenetic tests based on epigenetic biomarkers (i.e., DNA methylation, miRNAs, and histones) that can actually be implemented into clinical practice are compiled.
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The stem cell division theory of cancer.
TL;DR: The accumulation of cell divisions in stem cells drives not only the accumulation of the DNA alterations required for carcinogenesis, but also the formation and growth of the abnormal cell populations that characterize the disease.
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Journal ArticleDOI
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