Journal ArticleDOI
Golden age of insecticide research: past, present, or future?
John E. Casida,Gary B. Quistad +1 more
TLDR
Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.Abstract:
Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the organophosphates, methylcarbamates, and pyrethroids--all neuroactive chemicals. This Golden Age of Discovery was the source of most of our current insecticides. The challenge then became health and the environment, a Golden Age met with selective and degradable compounds. Next the focus shifted to resistance, novel biochemical targets, and new chemical approaches for pest control. The current Golden Age of Genetic Engineering has curtailed, but is unlikely to eliminate, chemical use on major crops. Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.read more
Citations
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Zinc and alpha-lipoic acid alleviate cypermethrin induced reproductive toxicity in mature male wistar rat
TL;DR: The results revealed the beneficial influences of zinc and α-lipoic acid in reducing the harmful effects of cypermethrin on male reproductive system of rat and restored the altered reproductive parameters towards normal levels.
Journal ArticleDOI
First evidence of insecticidal potential of molecules produced during the parasitic phase of the endoparasitoid Cotesia flavipes
TL;DR: There is an insecticidal potential in the hemolymph serum plus circulating cell contents of D. saccharalis larvae parasitized by C. flavipes and further investigations will be performed to identify, characterize, and uncover the biotechnological application of these molecules.
Journal ArticleDOI
Metabolism of metofluthrin in rats: II. Excretion, distribution and amount of metabolites.
Jun Abe,Yoshitaka Tomigahara,Hirokazu Tarui,Hirohisa Nagahori,Motohiro Kurosawa,Kenji Sugimoto,Naohiko Isobe +6 more
TL;DR: The overall metabolic profiles of metofluthrin were described and differences in metabolic breakdown between the isomers were identified and faster urinary excretion and elimination from blood were observed for the alcohol moiety than the acid moiety.
References
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Book ChapterDOI
Safer and more effective insecticides for the future
John E. Casida,Gary B. Quistad +1 more
TL;DR: The use of synthetic organic insecticides has served for the past half century as the principal means to control insect-borne diseases and minimize losses in food and fibre production from pest insect attack as mentioned in this paper.
Related Papers (5)
NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more