Journal ArticleDOI
Golden age of insecticide research: past, present, or future?
John E. Casida,Gary B. Quistad +1 more
TLDR
Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.Abstract:
Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the organophosphates, methylcarbamates, and pyrethroids--all neuroactive chemicals. This Golden Age of Discovery was the source of most of our current insecticides. The challenge then became health and the environment, a Golden Age met with selective and degradable compounds. Next the focus shifted to resistance, novel biochemical targets, and new chemical approaches for pest control. The current Golden Age of Genetic Engineering has curtailed, but is unlikely to eliminate, chemical use on major crops. Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.read more
Citations
More filters
Journal ArticleDOI
Effects of oral exposure of synthetic pyrethroid, cypermethrin on the behavior of F1-progeny in mice
TL;DR: Results show that cypermethrin at dose level of 10mg/kg/day can induce a significant risk to the offspring following treatment of F0-mice before mating.
Journal ArticleDOI
Agrochemicals with estrogenic endocrine disrupting properties: Lessons Learned?
TL;DR: Important issues that must be addressed in the evaluation and regulation of hormonally active agrochemicals including mixture effects, efforts to reduce vertebrate animal use, chemical prioritization, and improvements in hazard, exposure, and risk assessments are described.
Journal ArticleDOI
Reproductive toxicity and histopathological changes induced by lambda‐cyhalothrin in male mice
TL;DR: The results indicate that LCT has reproductive toxicity, hepatotoxicity, nephrotoxicity, and splenotoxicity in male mice at the tested doses.
Journal ArticleDOI
Effect of prenatal exposure of deltamethrin on the ontogeny of xenobiotic metabolizing cytochrome P450s in the brain and liver of offsprings.
TL;DR: The present data indicating alterations in the expression of xenobiotic metabolizing CYPs during development following prenatal exposure to deltamethrin may be of significance as these CYP enzymes have a role in regulating the levels of ligands that modulate growth, differentiation, and neuroendocrine functions.
Journal ArticleDOI
Pesticide use in ornamental production: what are the benefits?
James A. Bethke,Raymond A. Cloyd +1 more
TL;DR: Pest control in ornamental production is challenging owing to the diversity of crops grown, the desired aesthetic perfection, the potential economic loss due to failure and the multitude of arthropod pests encountered.
References
More filters
Book ChapterDOI
Safer and more effective insecticides for the future
John E. Casida,Gary B. Quistad +1 more
TL;DR: The use of synthetic organic insecticides has served for the past half century as the principal means to control insect-borne diseases and minimize losses in food and fibre production from pest insect attack as mentioned in this paper.
Related Papers (5)
NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more