Journal ArticleDOI
Golden age of insecticide research: past, present, or future?
John E. Casida,Gary B. Quistad +1 more
TLDR
Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.Abstract:
Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the organophosphates, methylcarbamates, and pyrethroids--all neuroactive chemicals. This Golden Age of Discovery was the source of most of our current insecticides. The challenge then became health and the environment, a Golden Age met with selective and degradable compounds. Next the focus shifted to resistance, novel biochemical targets, and new chemical approaches for pest control. The current Golden Age of Genetic Engineering has curtailed, but is unlikely to eliminate, chemical use on major crops. Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.read more
Citations
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Journal ArticleDOI
Inhibitory Effects of Carvone Isomers on the GABAA Receptor in Primary Cultures of Rat Cortical Neurons
TL;DR: Results confirm that, at least partially, the reported insecticidal activity of carvones may be explained by their interaction with the GABA(A) receptor at its noncompetitive blocker site.
Journal ArticleDOI
Comparative studies on mitochondrial electron transport chain complexes of Sitophilus zeamais treated with allyl isothiocyanate and calcium phosphide.
TL;DR: In vitro, AITC inhibited complex IV more significantly than complex I, indicating that mitochondrial complex IV is the primary target of A ITC, and that complex I is another potential target.
Journal ArticleDOI
Development of U.S. EPA method 527 for the analysis of selected pesticides and flame retardants in the UCMR survey.
TL;DR: The rationale for selection and inclusion of the various contaminants included in Method 527 is discussed and the challenges associated with developing analytical methods that will be used for the occurrence monitoring of such a diverse group of organic molecules are described.
Journal ArticleDOI
Influence of Nanomolar Deltamethrin on the Hallmarks of Primary Cultured Cortical Neuronal Network and the Role of Ryanodine Receptors.
Jing Zheng,Yiyi Yu,Wei Feng,Jing Li,Ju Liu,Chun-Lei Zhang,Yao Dong,Isaac N. Pessah,Zhengyu Cao +8 more
TL;DR: The findings suggested that RyRs were sensitive molecular targets of DM with functional consequences likely relevant for mediating abnormal neuronal network connectivity in vitro.
References
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Book ChapterDOI
Safer and more effective insecticides for the future
John E. Casida,Gary B. Quistad +1 more
TL;DR: The use of synthetic organic insecticides has served for the past half century as the principal means to control insect-borne diseases and minimize losses in food and fibre production from pest insect attack as mentioned in this paper.
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NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more