Journal ArticleDOI
Golden age of insecticide research: past, present, or future?
John E. Casida,Gary B. Quistad +1 more
TLDR
Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.Abstract:
Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the organophosphates, methylcarbamates, and pyrethroids--all neuroactive chemicals. This Golden Age of Discovery was the source of most of our current insecticides. The challenge then became health and the environment, a Golden Age met with selective and degradable compounds. Next the focus shifted to resistance, novel biochemical targets, and new chemical approaches for pest control. The current Golden Age of Genetic Engineering has curtailed, but is unlikely to eliminate, chemical use on major crops. Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.read more
Citations
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Journal ArticleDOI
Shoot-and-Trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography
Jacques-Philippe Colletier,Dominique Bourgeois,Benoît Sanson,Didier Fournier,Joel L. Sussman,Israel Silman,Martin Weik +6 more
TL;DR: Specific x-ray damage during temperature-controlled crystallographic experiments at a third-generation synchrotron source is used to trigger and monitor structural changes putatively involved in an enzymatic reaction.
Journal ArticleDOI
Effect of acaricides on the activity of a Boophilus microplus glutathione S-transferase.
Itabajara da Silva Vaz,Tiago Torino Lermen,André Michelon,Carlos A. Ferreira,Daniela Reis Joaquim de Freitas,Carlos Termignoni,Aoi Masuda +6 more
TL;DR: The effect of several acaricides on the enzyme activity of a Boophilus microplus recombinant glutathione S-transferase (rGST) is reported, which helps in understanding how acaricide can interact with GST.
Journal ArticleDOI
Prallethrin induced biochemical changes in erythrocyte membrane and red cell osmotic haemolysis in human volunteers.
TL;DR: Increases in generation and availability of nitric oxide might have rendered tolerance to erythrocyte membrane by protecting the cells from haemolysis and a significant decrease in membrane lipid peroxidation suggested that PS is a sensitive phospholipid species to the pyrethroid action.
Journal ArticleDOI
Plant-Derived Pesticides as an Alternative to Pest Management and Sustainable Agricultural Production: Prospects, Applications and Challenges.
Augusto Lopes Souto,Muriel Sylvestre,Elisabeth Dantas Tölke,Josean Fechine Tavares,José Maria Barbosa-Filho,Gerardo Cebrián-Torrejón +5 more
TL;DR: A critical review of plant-derived metabolites, along with their corresponding toxicology and mechanisms of action, will be approached, as well as the different strategies developed in order to meet the required commercial standards through more efficient methods as mentioned in this paper.
References
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Book ChapterDOI
Safer and more effective insecticides for the future
John E. Casida,Gary B. Quistad +1 more
TL;DR: The use of synthetic organic insecticides has served for the past half century as the principal means to control insect-borne diseases and minimize losses in food and fibre production from pest insect attack as mentioned in this paper.
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NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more