Journal ArticleDOI
Golden age of insecticide research: past, present, or future?
John E. Casida,Gary B. Quistad +1 more
TLDR
Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.Abstract:
Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the organophosphates, methylcarbamates, and pyrethroids--all neuroactive chemicals. This Golden Age of Discovery was the source of most of our current insecticides. The challenge then became health and the environment, a Golden Age met with selective and degradable compounds. Next the focus shifted to resistance, novel biochemical targets, and new chemical approaches for pest control. The current Golden Age of Genetic Engineering has curtailed, but is unlikely to eliminate, chemical use on major crops. Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.read more
Citations
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Journal ArticleDOI
Neurobehavioral toxicology of pyrethroid insecticides in adult animals: a critical review.
TL;DR: A synthesis of the neurobehavioral evidence relating to the action of pyrethroids indicates that some differences in the experimental findings across compounds are also present in the low-effective dose range.
Journal ArticleDOI
Overview of Carboxylesterases and Their Role in the Metabolism of Insecticides
TL;DR: It is expected that carboxylesterase research will increase with specific emphasis on isozyme and substrate identification, and the current state of the field is evaluated.
Journal ArticleDOI
Environmental fate and toxicology of organophosphate pesticides
TL;DR: A review of the literature shows that OPs are highly toxic and that human exposure is undesirable as mentioned in this paper, arguing for a thorough examination of the environmental fate and toxicology of OPs as well as their use.
Journal ArticleDOI
Increased cancer burden among pesticide applicators and others due to pesticide exposure.
TL;DR: The epidemiological, molecular biology, and toxicological evidence emerging from recent literature assessing the link between specific pesticides and several cancers including prostate cancer, non‐Hodgkin lymphoma, leukemia, multiple myeloma, and breast cancer are integrated.
Journal ArticleDOI
Invertebrate biomarkers: links to toxicosis that predict population decline
Ross V Hyne,William A. Maher +1 more
TL;DR: Evaluated biochemical biomarkers of impaired biological function in invertebrates should not be used as a replacement for conventional aquatic monitoring techniques, but should be applied as supplementary approaches for demonstrating links between sublethal biochemical and adverse effects in natural populations in field studies.
References
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Book ChapterDOI
Safer and more effective insecticides for the future
John E. Casida,Gary B. Quistad +1 more
TL;DR: The use of synthetic organic insecticides has served for the past half century as the principal means to control insect-borne diseases and minimize losses in food and fibre production from pest insect attack as mentioned in this paper.
Related Papers (5)
NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more