Journal ArticleDOI
Golden age of insecticide research: past, present, or future?
John E. Casida,Gary B. Quistad +1 more
TLDR
Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.Abstract:
Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the organophosphates, methylcarbamates, and pyrethroids--all neuroactive chemicals. This Golden Age of Discovery was the source of most of our current insecticides. The challenge then became health and the environment, a Golden Age met with selective and degradable compounds. Next the focus shifted to resistance, novel biochemical targets, and new chemical approaches for pest control. The current Golden Age of Genetic Engineering has curtailed, but is unlikely to eliminate, chemical use on major crops. Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.read more
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Journal ArticleDOI
Specificity and putative mode of action of a mosquito larvicidal toxin from the bacterium Xenorhabdus innexi.
Il Hwan Kim,Il Hwan Kim,Jerald C. Ensign,Do-Young Kim,Hoe-Yune Jung,Na-Ri Kim,Bo-Hwa Choi,Sun-Min Park,Que Lan,Walter G. Goodman +9 more
TL;DR: Specificity and toxicity towards mosquito larvae and the unique mode of action makes this lipopeptide a potentially attractive bacterial insecticide for control of mosquitoes.
Journal ArticleDOI
Acute toxicities of cadmium and permethrin on the pre-spawning and post-spawning phases of Hexaplex trunculus from Bizerta Lagoon, Tunisia
TL;DR: The results show that H. trunculus in post-spawning was more sensitive to cadmium and permethrin than in the pre- spawning phase, and the biochemical responses to pollutants (cadmium) represented by CAT may act as a biomarker of exposure in this species.
Journal ArticleDOI
Large Crystal Toxin Formation in Chromosomally Engineered Bacillus thuringiensis subsp. aizawai Due to σE Accumulation
TL;DR: The results from qPCR indicate clearly that the cry1Aa promoter activity was influenced most strongly by σE, whereas cry11Aa depended mostly on σK, and should provide useful information for the generation of strains with improved insecticidal activity.
Journal ArticleDOI
Structural determinants of imidacloprid-based nicotinic acetylcholine receptor inhibitors identified using 3D-QSAR, docking and molecular dynamics
Qinfan Li,Xiangya Kong,Zhengtao Xiao,Lihui Zhang,Fangfang Wang,Hong Zhang,Yan Li,Yonghua Wang +7 more
TL;DR: It is shown that amino acids located within loops A, C, D and E play key roles in the interaction of Dm-/Md-nAChR with NNs, highly consistent with the results of graphical analysis of 3D-QSAR contour plots.
Journal Article
Recent trends in control of ectoparasites: A review
TL;DR: The present review critically analyzes the different methods for controlling the ectoparasites with special emphasis on the newer approach of the biological, immunological, genetic and pheromone method.
References
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Book ChapterDOI
Safer and more effective insecticides for the future
John E. Casida,Gary B. Quistad +1 more
TL;DR: The use of synthetic organic insecticides has served for the past half century as the principal means to control insect-borne diseases and minimize losses in food and fibre production from pest insect attack as mentioned in this paper.
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NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
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