Journal ArticleDOI
Golden age of insecticide research: past, present, or future?
John E. Casida,Gary B. Quistad +1 more
TLDR
Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.Abstract:
Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the organophosphates, methylcarbamates, and pyrethroids--all neuroactive chemicals. This Golden Age of Discovery was the source of most of our current insecticides. The challenge then became health and the environment, a Golden Age met with selective and degradable compounds. Next the focus shifted to resistance, novel biochemical targets, and new chemical approaches for pest control. The current Golden Age of Genetic Engineering has curtailed, but is unlikely to eliminate, chemical use on major crops. Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.read more
Citations
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Journal ArticleDOI
Identification of Acylpeptide Hydrolase as a Sensitive Site for Reaction with Organophosphorus Compounds and a Potential Target for Cognitive Enhancing Drugs
TL;DR: It was possible to show that acylpeptide hydrolase is the only enzyme in the brain capable of hydrolyzing the substrate N-acetyl-alanyl-p-nitroanilide, and suggest that it may be the target for the cognitive-enhancing effects of certain organophosphorus compounds.
Journal ArticleDOI
Biology, ecology, and management of the bulb mites of the genus Rhizoglyphus (Acari: Acaridae)
TL;DR: Management of bulbmites is complicated by their short generation time, high reproductive potential, broad food niche, interactions with other pests and pathogens, and unique adaptations for dispersal.
Journal ArticleDOI
Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease.
TL;DR: The structure of Torpedo californica acetylcholinesterase is examined in complex with several inhibitors that are either in use or under development for treating Alzheimer's disease.
Journal ArticleDOI
Characterization of deltamethrin metabolism by rat plasma and liver microsomes
Sathanandam S. Anand,James V. Bruckner,Wendy T. Haines,Wendy T. Haines,Srinivasa Muralidhara,Jeffrey W. Fisher,Stephanie Padilla +6 more
TL;DR: The aims of this study were to identify, characterize, and assess the relative contributions of esterases and cytochrome P450s (CYP450s) responsible for deltamethrin metabolism by measuring deltAMethrin disappearance following incubation of various concentrations in plasma (esterases) and liver microsomes prepared from adult male rats.
Journal ArticleDOI
The relationship of 3-PBA pyrethroids metabolite and male reproductive hormones among non-occupational exposure males.
Yan Han,Yankai Xia,Jiayuan Han,Jinping Zhou,Shoulin Wang,Pengfei Zhu,Rencheng Zhao,Nianzu Jin,Ling Song,Xinru Wang +9 more
TL;DR: In adult men, urinary 3-PBA levels were associated with increased LH and reduced E2 levels, which suggested that pyrethroids are capable of disrupting the male endocrine function.
References
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Book ChapterDOI
Safer and more effective insecticides for the future
John E. Casida,Gary B. Quistad +1 more
TL;DR: The use of synthetic organic insecticides has served for the past half century as the principal means to control insect-borne diseases and minimize losses in food and fibre production from pest insect attack as mentioned in this paper.
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NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more