Journal ArticleDOI
Golden age of insecticide research: past, present, or future?
John E. Casida,Gary B. Quistad +1 more
TLDR
Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.Abstract:
Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the organophosphates, methylcarbamates, and pyrethroids--all neuroactive chemicals. This Golden Age of Discovery was the source of most of our current insecticides. The challenge then became health and the environment, a Golden Age met with selective and degradable compounds. Next the focus shifted to resistance, novel biochemical targets, and new chemical approaches for pest control. The current Golden Age of Genetic Engineering has curtailed, but is unlikely to eliminate, chemical use on major crops. Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.read more
Citations
More filters
Journal ArticleDOI
The locust genome provides insight into swarm formation and long-distance flight
Xianhui Wang,Xiaodong Fang,Pengcheng Yang,Xuanting Jiang,Feng Jiang,Dejian Zhao,Bolei Li,Feng Cui,Jianing Wei,Chuan Ma,Wang Yundan,Jing He,Yuan Luo,Zhifeng Wang,Xiaojiao Guo,Wei Guo,Xuesong Wang,Yi Zhang,Meiling Yang,Shuguang Hao,Bing Chen,Zongyuan Ma,Dan Yu,Zhiqiang Xiong,Yabing Zhu,Dingding Fan,Lijuan Han,Bo Wang,Yuanxin Chen,Junwen Wang,Lan Yang,Wei Zhao,Yue Feng,Guanxing Chen,Jinmin Lian,Qiye Li,Zhiyong Huang,Xiaoming Yao,Na Lv,Guojie Zhang,Yingrui Li,Jian Wang,Jun Wang,Baoli Zhu,Le Kang +44 more
TL;DR: A draft 6.5 Gb genome sequence of Locusta migratoria is presented, which is the largest animal genome sequenced so far, and complex regulatory mechanisms involved in microtubule dynamic-mediated synapse plasticity during phase change are revealed.
Journal ArticleDOI
A Biopolymer Chitosan and Its Derivatives as Promising Antimicrobial Agents against Plant Pathogens and Their Applications in Crop Protection
TL;DR: In this paper, the authors present an overview of the antimicrobial effects, mechanisms, and applications of a biopolymer chitosan and its derivatives in crop protection, and take a closer look at the physiochemical properties and chemical modifications of chitosa molecule.
Journal ArticleDOI
Pest Toxicology: The Primary Mechanisms of Pesticide Action
TL;DR: Pesticides are used to control pests before they harm us or the authors' crops, and an understanding of comparative biochemistry and molecular toxicology considering pests, people, and crops is required.
Journal ArticleDOI
Three‐dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors
Michal Harel,Gitay Kryger,Terrone L. Rosenberry,William D. Mallender,Terence Lewis,Rodney J. Fletcher,J. Mitchell Guss,Israel Silman,Joel L. Sussman +8 more
TL;DR: The refined structure of D. melanogaster acetylcholinesterase is similar to that of vertebrates, but some of the surface loops deviate by up to 8 Å from their position in the vertebrate structures, and the C‐terminal helix is shifted substantially.
Journal ArticleDOI
Impact of environment on mosquito response to pyrethroid insecticides: Facts, evidences and prospects
TL;DR: Current knowledge on pyrethroid resistance mechanisms in mosquitoes is updated and available data on the impact of the environment on mosquito response to pyrethroids, including key environmental factors, such as the presence of urban or agricultural pollutants and biotic interactions between mosquitoes and their microbiome are discussed, and research perspectives to fill in knowledge gaps are suggested.
References
More filters
Book ChapterDOI
Safer and more effective insecticides for the future
John E. Casida,Gary B. Quistad +1 more
TL;DR: The use of synthetic organic insecticides has served for the past half century as the principal means to control insect-borne diseases and minimize losses in food and fibre production from pest insect attack as mentioned in this paper.
Related Papers (5)
NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more