Journal ArticleDOI
Golden age of insecticide research: past, present, or future?
John E. Casida,Gary B. Quistad +1 more
TLDR
Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.Abstract:
Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the organophosphates, methylcarbamates, and pyrethroids--all neuroactive chemicals. This Golden Age of Discovery was the source of most of our current insecticides. The challenge then became health and the environment, a Golden Age met with selective and degradable compounds. Next the focus shifted to resistance, novel biochemical targets, and new chemical approaches for pest control. The current Golden Age of Genetic Engineering has curtailed, but is unlikely to eliminate, chemical use on major crops. Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.read more
Citations
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Dissertation
Novel epoxide-based glutamate agonist class of pesticide: Synthesis, binding mechanism, and potency
Posted ContentDOI
Discovery of malathion resistance QTL in <i>Drosophila melanogaster</i> using a bulked phenotyping approach
TL;DR: In this article , the authors use Drosophila melanogaster and leverage a bulk phenotyping and pooled sequencing approach to genetically dissect variation in resistance to malathion, an organophosphate insecticide.
Journal ArticleDOI
PLS Structure-Insecticidal Activity Relationships of Nitromethylene, Pyrrole- and Dihydropyrrole-Fused Neonicotinoids
TL;DR: In this article, the partial least squares (PLS) approach is applied to a series of nitromethylene, pyrrole- and dihydropyrrole fused neonicotinoids to model their insecticidal activity (pLC50 values) against cowpea aphids.
Journal ArticleDOI
Perspectives of vector management in the control and elimination of vector-borne zoonoses
Meng Li Wong,Zulhisham Zulzahrin,Indra Vythilingam,Yee Ling Lau,I-Ching Sam,Mun Yik Fong,Wenn-Chyau Lee +6 more
TL;DR: In this paper , the authors highlighted differences among the environmental, chemical, and biological control approaches in vector management, from the perspectives of vector-borne zoonoses (VZB) and VBIAR.
Journal ArticleDOI
Self-assembled thiophanate-methyl/star polycation complex prevents plant cell-wall penetration and fungal carbon utilization during cotton infection by Verticillium dahliae.
Xiaofeng Su,Shuo Yan,Weisong Zhao,Haiyang Liu,Qinhong Jiang,Huiming Guo,Meizhen Yin,Jie Shen +7 more
TL;DR: In this paper , a star polycation-based nanodelivery system was used for the first time to develop a thiophanate-methyl (TM) nanoagent for the management of Verticillium dahliae, which causes vascular wilt disease.
References
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Book ChapterDOI
Safer and more effective insecticides for the future
John E. Casida,Gary B. Quistad +1 more
TL;DR: The use of synthetic organic insecticides has served for the past half century as the principal means to control insect-borne diseases and minimize losses in food and fibre production from pest insect attack as mentioned in this paper.
Related Papers (5)
NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more