Journal ArticleDOI
Golden age of insecticide research: past, present, or future?
John E. Casida,Gary B. Quistad +1 more
TLDR
Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.Abstract:
Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the organophosphates, methylcarbamates, and pyrethroids--all neuroactive chemicals. This Golden Age of Discovery was the source of most of our current insecticides. The challenge then became health and the environment, a Golden Age met with selective and degradable compounds. Next the focus shifted to resistance, novel biochemical targets, and new chemical approaches for pest control. The current Golden Age of Genetic Engineering has curtailed, but is unlikely to eliminate, chemical use on major crops. Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.read more
Citations
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Journal ArticleDOI
Cypermethrin induces astrocyte apoptosis by the disruption of the autocrine/paracrine mode of epidermal growth factor receptor signaling.
Shailendra Kumar Maurya,Asit Rai,Nagendra Kumar Rai,Shreekant Deshpande,Rajeev Jain,Mohana Krishna Reddy Mudiam,Yenamandra S. Prabhakar,Sanghamitra Bandyopadhyay +7 more
TL;DR: It is demonstrated that cypermethrin induces astrocyte apoptosis by disrupting the autocrine/paracrine mode of HB-EGF-EGFR signaling at two levels, irreversible loss of basal EGFR and downregulation of HB -EGF.
Journal ArticleDOI
A gene and drug co-delivery application helps to solve the short life disadvantage of RNA drug
TL;DR: In this article , a star polycation-based gene/drug delivery system was constructed for co-delivering hemocytin (hem) dsRNA and botanical pesticide matrine to develop a novel multicomponent nano-pesticide for achieving sequential bioactivity against devastating green peach aphids.
Journal ArticleDOI
Bruchid pest management in pulses: past practices, present status and use of modern breeding tools for development of resistant varieties
Sujit K. Mishra,Maria Lígia Rodrigues Macedo,Sanjib Kumar Panda,Jogeswar Panigrahi,Jogeswar Panigrahi +4 more
TL;DR: The present study discusses the pros and cons of different approaches for the successful management of the bruchid pests in pulses, and highlights about the integrative approach aided with molecular interventions to improve productivity by avoiding losses incurred due to bruchids, and to attain sustainable yields for major pulse crops.
Journal ArticleDOI
Delivery of intrahemocoelic peptides for insect pest management.
TL;DR: Recent developments for appropriate delivery of insect-specific insecticidal peptides via fusion to a second protein such as a plant lectin or a luteovirus coat protein for transcytosis across the gut epithelium, or via entomopathogenic fungi are summarized.
Journal ArticleDOI
The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster.
Emily J. Remnant,Emily J. Remnant,Craig J. Morton,Phillip J. Daborn,Christopher Lumb,Ying Ting Yang,Hooi Ling Ng,Michael W. Parker,Philip J. Batterham +8 more
TL;DR: It is confirmed that point mutations at the Rdl 301 site provide moderate resistance to phenylpyrazoles in D. melanogaster, and the beneficial aspects of testing predicted mutations in a whole organism to validate a candidate gene approach are emphasized.
References
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Book ChapterDOI
Safer and more effective insecticides for the future
John E. Casida,Gary B. Quistad +1 more
TL;DR: The use of synthetic organic insecticides has served for the past half century as the principal means to control insect-borne diseases and minimize losses in food and fibre production from pest insect attack as mentioned in this paper.
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NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more