Journal ArticleDOI
Golden age of insecticide research: past, present, or future?
John E. Casida,Gary B. Quistad +1 more
TLDR
Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.Abstract:
Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the organophosphates, methylcarbamates, and pyrethroids--all neuroactive chemicals. This Golden Age of Discovery was the source of most of our current insecticides. The challenge then became health and the environment, a Golden Age met with selective and degradable compounds. Next the focus shifted to resistance, novel biochemical targets, and new chemical approaches for pest control. The current Golden Age of Genetic Engineering has curtailed, but is unlikely to eliminate, chemical use on major crops. Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.read more
Citations
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Book ChapterDOI
Receptors for neuronal or endocrine signalling molecules as potential targets for the control of insect pests.
Heleen Verlinden,Rut Vleugels,Sven Zels,Senne Dillen,Cynthia Lenaerts,Katleen Crabbé,Jornt Spit,Jozef Vanden Broeck +7 more
TL;DR: This review will address this issue and enumerate reasons why it would be worth investing more in insect GPCRs, the largest category of signal transducing receptors that controls virtually every physiological process in metazoans.
Journal ArticleDOI
Additivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture.
TL;DR: In vitro relative potency and efficacy measurements for 7 pyrethroid compounds in intact mammalian neurons are provided, and the action of a mixture of all 11 pyrethroids to be additive when used an appropriate statistical model.
Journal ArticleDOI
Synthesis and structure–activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors
Cyril Ronco,Cyril Ronco,Geoffroy Sorin,Geoffroy Sorin,Florian Nachon,Richard Foucault,Ludovic Jean,Ludovic Jean,Anthony Romieu,Anthony Romieu,Pierre-Yves Renard,Pierre-Yves Renard,Pierre-Yves Renard +12 more
TL;DR: New series of Huprine derivatives have been synthesized and their inhibiting activities toward recombinant human acetylcholinesterase (rh-AChE) are reported and variations of activity between the different linkers suggest future structural modifications for activity improvement.
Journal ArticleDOI
The pyrethroid pesticide esfenvalerate suppresses the afternoon rise of luteinizing hormone and delays puberty in female rats.
TL;DR: Although the hypothalamus is able to respond to exogenous stimuli, absence of a normal afternoon rise in LH would indicate a hypothalamic deficit in ESF-treated animals.
Journal ArticleDOI
Baseline susceptibility of Bemisia tabaci B biotype (Hemiptera: Aleyrodidae) populations from California and Arizona to spiromesifen.
TL;DR: A regional baseline that can serve as a reference for future monitoring and management of B. tabaci resistance to spirotetramat is established for Arizona and California in 2008 and 2009.
References
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Book ChapterDOI
Safer and more effective insecticides for the future
John E. Casida,Gary B. Quistad +1 more
TL;DR: The use of synthetic organic insecticides has served for the past half century as the principal means to control insect-borne diseases and minimize losses in food and fibre production from pest insect attack as mentioned in this paper.
Related Papers (5)
NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more