Journal ArticleDOI
Golden age of insecticide research: past, present, or future?
John E. Casida,Gary B. Quistad +1 more
TLDR
Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.Abstract:
Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the organophosphates, methylcarbamates, and pyrethroids--all neuroactive chemicals. This Golden Age of Discovery was the source of most of our current insecticides. The challenge then became health and the environment, a Golden Age met with selective and degradable compounds. Next the focus shifted to resistance, novel biochemical targets, and new chemical approaches for pest control. The current Golden Age of Genetic Engineering has curtailed, but is unlikely to eliminate, chemical use on major crops. Insecticide research, having passed through several Golden Ages, is now in a renaissance of integrating chemicals and biologicals for sustainable pest control with human safety.read more
Citations
More filters
Journal ArticleDOI
Crystal Structure of Thioflavin T Bound to the Peripheral Site of Torpedo Californica Acetylcholinesterase Reveals How Thioflavin T Acts as a Sensitive Fluorescent Reporter of Ligand Binding to the Acylation Site.
TL;DR: The X-ray structure of the complex of thioflavin T with Torpedo californica acetylcholinesterase is reported, which indicates that the phenyl side chain of Phe330 must rotate to sterically accommodate both thioFLavin T and the A-site ligand in the ternary complex.
Journal ArticleDOI
Mechanism of Pyrethroid Pesticide–Induced Apoptosis: Role of Calpain and the ER Stress Pathway
TL;DR: Data demonstrate that deltamethrin causes apoptosis through its interaction with Na⁺ channels, leading to calcium overload and activation of the ER stress pathway, and provides mechanistic information by which high-level exposure to pyrethroids may contribute to neurodegeneration.
Journal ArticleDOI
Insecticide resistance status in the whitefly, Bemisia tabaci genetic groups Asia-I, Asia-II-1 and Asia-II-7 on the Indian subcontinent.
N. C. Naveen,Rahul Chaubey,Dinesh Kumar,K. B. Rebijith,Raman Rajagopal,B. Subrahmanyam,Sankar Subramanian +6 more
TL;DR: The present study is a summary of the current level of the insecticide resistance to selected organophosphates, pyrethroids, and neonicotinoids in seven Indian field populations of B. tabaci, with Asia-II-7 being the most susceptible, while Asia-I and Asia- II-1 populations were showing significant resistance to these insecticides.
Journal ArticleDOI
Developmental neurotoxicity of succeeding generations of insecticides.
TL;DR: This review covers the developmental neurotoxicity of the succeeding generations of insecticides including organochlorines, organophosphates, pyrethroids, carbamates and neonicotinoids.
Journal ArticleDOI
Learning from the past and considering the future of chemicals in the environment.
TL;DR: Researchers still struggle to establish whether the nonlethal effects associated with some modern chemicals and substances will have serious consequences for wildlife, and obtaining the resources to address issues associated with chemicals in the environment remains a challenge.
References
More filters
Book ChapterDOI
Safer and more effective insecticides for the future
John E. Casida,Gary B. Quistad +1 more
TL;DR: The use of synthetic organic insecticides has served for the past half century as the principal means to control insect-borne diseases and minimize losses in food and fibre production from pest insect attack as mentioned in this paper.
Related Papers (5)
NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more