Histone H3.1 and H3.3 Complexes Mediate Nucleosome Assembly Pathways Dependent or Independent of DNA Synthesis
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TLDR
Deposition of the major histone H3 (H3.1) is coupled to DNA synthesis during DNA replication and possibly DNA repair, whereas histone variant H3.3 serves as the replacement variant for the DNA-synthesis-independent deposition pathway, and purified deposition machineries for these histones are presented.About:
This article is published in Cell.The article was published on 2004-01-09 and is currently open access. It has received 1238 citations till now. The article focuses on the topics: Histone code & Nucleosome assembly.read more
Citations
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Journal ArticleDOI
The molecular hallmarks of epigenetic control
C. David Allis,Thomas Jenuwein +1 more
TL;DR: A personal perspective on the development of epigenetics, from its historical origins to what is defined as 'the modern era of epigenetic research', is provided.
Journal ArticleDOI
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.
Michael J. Carrozza,Bing Li,Laurence Florens,Tamaki Suganuma,Selene K. Swanson,Kenneth K. Lee,Wei-Jong Shia,Scott Anderson,John R. Yates,Michael P. Washburn,Jerry L. Workman +10 more
TL;DR: Data indicate that Pol II-associated Set2 methylates H3 providing a transcriptional memory which signals for deacetylation of ORFs by Rpd3S, which erases transcription elongation-associated acetylation to suppress intragenic transcription initiation.
Journal ArticleDOI
Histones and histone modifications.
TL;DR: Future studies will no doubt continue to identify the functional and biochemical properties of new chromatin domains as well as to elucidate the principles that govern their maintenance and propagation.
Journal ArticleDOI
Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
Aaron D Goldberg,Laura A. Banaszynski,Kyung-Min Noh,Peter W. Lewis,Simon J. Elsaesser,Sonja C. Stadler,Scott Dewell,Martin J. Law,Xingyi Guo,Xuan Li,Duancheng Wen,Duancheng Wen,Ariane Chapgier,Russell Dekelver,Jeffrey C. Miller,Ya Li Lee,Elizabeth A. Boydston,Michael C. Holmes,Philip D. Gregory,John M. Greally,Shahin Rafii,Shahin Rafii,Chingwen Yang,Peter J. Scambler,David Garrick,Richard J. Gibbons,Douglas R. Higgs,Ileana M. Cristea,Fyodor D. Urnov,Deyou Zheng,C. David Allis +30 more
TL;DR: It is demonstrated that multiple and distinct factors are responsible for H3.3 localization at specific genomic locations in mammalian cells.
Journal ArticleDOI
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
Gunnar Schotta,Monika Lachner,Kavitha Sarma,Anja Ebert,Roopsha Sengupta,Gunter Reuter,Danny Reinberg,Thomas Jenuwein +7 more
TL;DR: Together, the data indicate a function for H4-K20 trimethylation in gene silencing and further suggest H3-K9 and H4,K20 trimmedethylation as important components of a repressive pathway that can index pericentric heterochromatin.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
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Correlation between Protein and mRNA Abundance in Yeast
TL;DR: The results clearly delineate the technical boundaries of current approaches for quantitative analysis of protein expression and reveal that simple deduction from mRNA transcript analysis is insufficient to predict protein expression levels from quantitative mRNA data.
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Histone acetylation and an epigenetic code
TL;DR: Recent evidence raises the interesting possibility that an acetylation-based code may operate through both mitosis and meiosis, providing a possible mechanism for germ-line transmission of epigenetic changes.
Journal ArticleDOI
The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly.
Kami Ahmad,Steven Henikoff +1 more
TL;DR: A mechanism of chromatin regulation whereby the variant H3.3 is deposited at particular loci, including active rDNA arrays, providing a mechanism for the immediate activation of genes that are silenced by histone modification.
BookDOI
Chromatin structure and function
TL;DR: The Chromatin Pattern in Situ: Dependence upon Cell Cycle, Preimplantation and Development, and Cellular Aging in Vitro, and Generalized Biological Effects.
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