Host Response to Translocated Microbial Products Predicts Outcomes of Patients With HBV or HCV Infection
Netanya G. Sandler,Christopher Koh,Annelys Roque,Jason L. Eccleston,Rebecca B. Siegel,Mary DeMino,David E. Kleiner,Steven G. Deeks,T. Jake Liang,Theo Heller,Daniel C. Douek +10 more
TLDR
LPS-induced local and systemic inflammation is associated with cirrhosis and predicts progression to end-stage liver disease in patients with HBV or HCV infection.About:
This article is published in Gastroenterology.The article was published on 2011-10-01 and is currently open access. It has received 276 citations till now. The article focuses on the topics: Cirrhosis & Hepatitis B.read more
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Intestinal epithelial cells: regulators of barrier function and immune homeostasis
Lance W. Peterson,David Artis +1 more
TL;DR: This Review provides a comprehensive overview of how IECs maintain host–commensal microbial relationships and immune cell homeostasis in the intestine.
Journal ArticleDOI
Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria
Gregory F. Sonnenberg,Laurel A. Monticelli,Theresa Alenghat,Thomas C. Fung,Natalie A. Hutnick,Jun Kunisawa,Naoko Shibata,Stephanie Grunberg,Rohini Sinha,Adam M. Zahm,Mélanie R. Tardif,Taheri Sathaliyawala,Masaru Kubota,Donna L. Farber,Ronald G. Collman,Abraham Shaked,Lynette A. Fouser,David B. Weiner,Philippe A. Tessier,Joshua R. Friedman,Hiroshi Kiyono,Frederic D. Bushman,Kyong-Mi Chang,Kyong-Mi Chang,David Artis +24 more
TL;DR: It is shown that interleukin-22 (IL-22)–producing innate lymphoid cells (ILCs) are present in intestinal tissues of healthy mammals, indicating that ILCs regulate selective containment of lymphoid-resident bacteria to prevent systemic inflammation associated with chronic diseases.
Journal ArticleDOI
Systemic Effects of Inflammation on Health during Chronic HIV Infection
TL;DR: It is likely that knowledge gained on how inflammation affects health in HIV disease could have implications for the understanding of other chronic inflammatory diseases and the biology of aging.
Journal ArticleDOI
Pathological bacterial translocation in liver cirrhosis.
TL;DR: There appears to exist a hierarchy of three barriers against pathological BT, each of which encompasses a distinct set of mechanisms and involves the rapid detection and killing of bacteria that manage to penetrate.
Journal ArticleDOI
Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis
Erica Villa,Calogero Cammà,Marco Marietta,Monica Luongo,Rosina Maria Critelli,Stefano Colopi,Cristina Tata,Ramona Zecchini,Stefano Gitto,Salvatore Petta,Barbara Lei,Veronica Bernabucci,Ranka Vukotic,Nicola De Maria,Filippo Schepis,Aimilia Karampatou,Cristian Caporali,Luisa Simoni,Mariagrazia Del Buono,Beatrice Zambotto,Elena Turola,Giovanni Fornaciari,Susanna Schianchi,Anna Ferrari,Dominique Valla,Dominique Valla +25 more
TL;DR: In this article, a randomized controlled trial was performed to evaluate the safety and efficacy of enoxaparin, a low-molecular-weight heparin, in preventing portal vein thrombosis (PVT) in patients with advanced cirrhosis.
References
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Histological grading and staging of chronic hepatitis.
Kamal G. Ishak,Amelia Baptista,Leonardo Bianchi,Francesco Callea,Jan De Groote,Fred Gudat,Helmut Denk,Valeer Desmet,Gerhard Korb,R. N. M. Macsween,M. James Phillips,Bernard G. Portmann,H. Poulsen,Peter J. Scheuer,Martin Schmid,Heribert Thaler +15 more
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Chronic hepatitis B: Update 2009
Anna S.F. Lok,Brian J. McMahon +1 more
TL;DR: The 2009 update of the American Association for the Study of Liver Diseases (AASLD) Practice Guidelines for Management of Chronic Hepatitis B is now posted online at www.aasld.org, and the recommendation for first-line oral antiviral medications has been changed to tenofovir or entecavir, and adefovir has been moved to second-line Oral antiviral medication.
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TLR4 enhances TGF-beta signaling and hepatic fibrosis.
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TL;DR: Modulation of TGF-β signaling by a TLR4-MyD88–NF-κB axis provides a novel link between proinflammatory and profibrogenic signals.
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Jason M. Brenchley,David Price,Timothy W. Schacker,Tedi E. Asher,Guido Silvestri,Srinivas S. Rao,Zachary Kazzaz,Ethan Bornstein,Olivier Lambotte,Daniel M. Altmann,Bruce R. Blazar,Benigno Rodriguez,Leia Teixeira-Johnson,Alan L. Landay,Jeffrey N. Martin,Frederick Hecht,Louis J. Picker,Michael M. Lederman,Steven G. Deeks,Daniel C. Douek +19 more