Journal ArticleDOI
Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies
Steven D. Schwartz,Carl D. Regillo,Byron L. Lam,Dean Eliott,Philip J. Rosenfeld,Ninel Z. Gregori,Jean-Pierre Hubschman,Janet L. Davis,Gad Heilwell,Marc J. Spirn,Joseph I. Maguire,Jane Bateman,Rosaleen Ostrick,Debra Morris,Matthew Vincent,Eddy Anglade,Lucian V. Del Priore,Robert Lanza +17 more
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The results suggest that hESC-derived cells could provide a potentially safe new source of cells for the treatment of various unmet medical disorders requiring tissue repair or replacement.About:
This article is published in The Lancet.The article was published on 2015-02-07. It has received 990 citations till now. The article focuses on the topics: Macular dystrophy & Stargardt disease.read more
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Journal ArticleDOI
Single Intravitreal Injection of Etamsylate for the Treatment of Geographic Atrophy Associated with Submacular Hemorrhage
Cuevas Sanchez Pedro,Outeiriño Luis,Azanza Carlos,Angulo-Frutos Javier,Cuevas-Bourdier Adrián,Gimenez-Gallego Guillermo +5 more
TL;DR: The efficacy of a single intravitreal injection of etamsylate, an anti-inflammatory drug, is shown in a patient with GA associated submacular hemorrhage in a patients with dry AMD.
Journal ArticleDOI
Caffeic acid selectively eliminates teratogenic human-induced pluripotent stem cells via apoptotic cell death.
TL;DR: In this paper , the beneficial effects of Caffeic acid in iPSC-based cell therapy, such as the selective elimination of iPSCs and anti-teratoma effects, have not yet been explored.
Book ChapterDOI
The therapeutic potential of exogenous adult stem cells for the injured central nervous system
Jayden Smith,Alice Braga,Regan Hamel,Carola Rutigliani,Bryan Yu,Luca Peruzzotti-Jametti,Stefano Pluchino +6 more
TL;DR: Clinical translation has thus far been impeded by only modest efficacy outcomes in clinical trials, speaking to a need for greater consistency and controls in such studies.
Book ChapterDOI
How the transplant landscape is changing in the regenerative medicine era
Paula A. Grisales,Justine Mariam Aziz,Sean M Muir,Domenica Ida Marino,Catherine La Pointe,Amish Asthana,Giuseppe Orlando +6 more
TL;DR: Regenerative medicine will enable organ-on-demand whereby patients will receive organs that will not be rejected and in a timely fashion, which will make registration in the waiting list and antirejection medications unnecessary and, as the new organs will be implanted immediately after fabrication, ischemia-reperfusion injury secondary to organ preservation will not been a problem anymore.
Journal ArticleDOI
Upcoming Therapies for Age-related Macular Degeneration.
Meghan Saumur,Christina Y. Weng +1 more
TL;DR: Age-related macular degeneration is one of the leading causes of vision loss, affecting ~6.5% of the United States population, or over 7 million people, and is the third leading cause of global blindness after cataracts and glaucoma.
References
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
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Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
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Establishment in culture of pluripotential cells from mouse embryos
TL;DR: The establishment in tissue culture of pluripotent cell lines which have been isolated directly from in vitro cultures of mouse blastocysts are reported, able to differentiate either in vitro or after innoculation into a mouse as a tumour in vivo.
Journal ArticleDOI
The Retinal Pigment Epithelium in Visual Function
TL;DR: This review summarizes the current knowledge of RPE functions and describes how failure of these functions causes loss of visual function.
Journal ArticleDOI
Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
Albert M. Maguire,Francesca Simonelli,Eric A. Pierce,Edward N. Pugh,Federico Mingozzi,Jeannette L. Bennicelli,Sandro Banfi,Kathleen A. Marshall,Francesco Testa,Enrico Maria Surace,Settimio Rossi,Arkady Lyubarsky,Valder R. Arruda,Barbara A. Konkle,Edwin M. Stone,Edwin M. Stone,Junwei Sun,Jonathan B. Jacobs,L. F. Dell'Osso,Richard W. Hertle,Jian Xing Ma,T. Michael Redmond,Xiaosong Zhu,Bernd Hauck,Olga Zelenaia,Kenneth S. Shindler,Maureen G. Maguire,J. Fraser Wright,Nicholas J. Volpe,Jennifer Wellman McDonnell,Alberto Auricchio,Katherine A. High,Katherine A. High,Jean Bennett +33 more
TL;DR: This study investigated the safety of subretinal delivery of a recombinant adeno-associated virus (AAV) carrying RPE65 complementary DNA (cDNA) and found three patients with LCA2 had an acceptable local and systemic adverse-event profile after delivery of AAV2.hRPE65v2.
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