Journal ArticleDOI
Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies
Steven D. Schwartz,Carl D. Regillo,Byron L. Lam,Dean Eliott,Philip J. Rosenfeld,Ninel Z. Gregori,Jean-Pierre Hubschman,Janet L. Davis,Gad Heilwell,Marc J. Spirn,Joseph I. Maguire,Jane Bateman,Rosaleen Ostrick,Debra Morris,Matthew Vincent,Eddy Anglade,Lucian V. Del Priore,Robert Lanza +17 more
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TLDR
The results suggest that hESC-derived cells could provide a potentially safe new source of cells for the treatment of various unmet medical disorders requiring tissue repair or replacement.About:
This article is published in The Lancet.The article was published on 2015-02-07. It has received 990 citations till now. The article focuses on the topics: Macular dystrophy & Stargardt disease.read more
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Stem Cell Therapies in Clinical Trials: Progress and Challenges
TL;DR: Clinical investigations using stem cell products in regenerative medicine are addressing a wide spectrum of conditions using a variety of stem cell types and applications are progressing in trials, some with early benefits to patients.
Journal ArticleDOI
Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
Michiko Mandai,Akira Watanabe,Yasuo Kurimoto,Yasuhiko Hirami,Chikako Morinaga,Takashi Daimon,Masashi Fujihara,Hiroshi Akimaru,Noriko Sakai,Yumiko Shibata,Motoki Terada,Yui Nomiya,Shigeki Tanishima,Masahiro Nakamura,Hiroyuki Kamao,Sunao Sugita,Akishi Onishi,Tomoko Ito,Kanako Fujita,Shin Kawamata,Masahiro J. Go,Chikara Shinohara,Kenichiro Hata,Masanori Sawada,Midori Yamamoto,Sachiko Ohta,Yasuo Ohara,Kenichi Yoshida,Junko Kuwahara,Yuko Kitano,Naoki Amano,Masafumi Umekage,Fumiyo Kitaoka,Azusa Tanaka,Chihiro Okada,Naoko Takasu,Seishi Ogawa,Shinya Yamanaka,Masayo Takahashi +38 more
TL;DR: At 1 year after surgery, the transplanted sheet of retinal pigment epithelial cells remained intact, best corrected visual acuity had not improved or worsened, and cystoid macular edema was present.
Journal ArticleDOI
Stem cells: past, present, and future.
TL;DR: A wide variety of possibilities makes this cutting edge therapy a turning point in modern medicine, providing hope for untreatable diseases and challenges that stem cell therapy must overcome to be accepted worldwide.
Journal ArticleDOI
Gene therapy clinical trials worldwide to 2017: An update
Samantha L. Ginn,Anais K. Amaya,Ian E. Alexander,Ian E. Alexander,Michael Edelstein,Mohammad R. Abedi +5 more
TL;DR: This review presents the analysis of clinical trials that, to the best of the knowledge, have been or are being performed worldwide, and discusses key trends since the previous review, namely the use of chimeric antigen receptor T cells for the treatment of cancer and advancements in genome editing technologies.
Journal ArticleDOI
Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration.
Lyndon da Cruz,Kate Fynes,Odysseas Georgiadis,Odysseas Georgiadis,Odysseas Georgiadis,Julie Kerby,Yvonne Hsu-Lin Luo,Yvonne Hsu-Lin Luo,Yvonne Hsu-Lin Luo,Ahmad Ahmado,Amanda J. Vernon,Julie T. Daniels,Britta Nommiste,Shazeen M Hasan,Sakina B Gooljar,Amanda-Jayne F. Carr,Anthony A. Vugler,Conor M. Ramsden,Conor M. Ramsden,Magda Bictash,Mike Fenster,Juliette Steer,Tricia Harbinson,Anna Wilbrey,Adnan Tufail,Adnan Tufail,Gang Feng,Mark Whitlock,Anthony G. Robson,Anthony G. Robson,Graham E. Holder,Graham E. Holder,Mandeep S. Sagoo,Mandeep S. Sagoo,Peter T. Loudon,Paul J. Whiting,Paul J. Whiting,Peter J. Coffey,Peter J. Coffey,Peter J. Coffey +39 more
TL;DR: This work supports the feasibility and safety of hESC-RPE patch transplantation as a regenerative strategy for AMD and presents the preclinical surgical, cell safety and tumorigenicity studies leading to trial approval.
References
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Lensectomy and vitrectomy decrease the rate of photoreceptor loss in rhodopsin P347L transgenic pigs.
Tamer H. Mahmoud,Brooks W. McCuen,Ying Hao,Suk Jin Moon,Misako Tatebayashi,Sandra S. Stinnett,Robert M. Petters,Fulton Wong +7 more
TL;DR: Lensectomy and vitrectomy delay photoreceptor degeneration in rhodopsin P347L transgenic pigs, and lens-related rescue effect is a probable reason for the delayed degeneration.
Journal ArticleDOI
Xenotransplantation of retinal pigment epithelial cells into RCS rats.
Salvatore Grisanti,Peter Szurman,Jens Jordan,Norbert Kociok,Karl Ulrich Bartz-Schmidt,Klaus Heimann +5 more
TL;DR: Subretinal RPE xenografts are protected from a strong cellular rejection, but seem to undergo a slow functional deterioration, reflected by a decline in their capability to rescue adjacent photoreceptors.
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Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
Michiko Mandai,Akira Watanabe,Yasuo Kurimoto,Yasuhiko Hirami,Chikako Morinaga,Takashi Daimon,Masashi Fujihara,Hiroshi Akimaru,Noriko Sakai,Yumiko Shibata,Motoki Terada,Yui Nomiya,Shigeki Tanishima,Masahiro Nakamura,Hiroyuki Kamao,Sunao Sugita,Akishi Onishi,Tomoko Ito,Kanako Fujita,Shin Kawamata,Masahiro J. Go,Chikara Shinohara,Kenichiro Hata,Masanori Sawada,Midori Yamamoto,Sachiko Ohta,Yasuo Ohara,Kenichi Yoshida,Junko Kuwahara,Yuko Kitano,Naoki Amano,Masafumi Umekage,Fumiyo Kitaoka,Azusa Tanaka,Chihiro Okada,Naoko Takasu,Seishi Ogawa,Shinya Yamanaka,Masayo Takahashi +38 more