Journal ArticleDOI
Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies
Steven D. Schwartz,Carl D. Regillo,Byron L. Lam,Dean Eliott,Philip J. Rosenfeld,Ninel Z. Gregori,Jean-Pierre Hubschman,Janet L. Davis,Gad Heilwell,Marc J. Spirn,Joseph I. Maguire,Jane Bateman,Rosaleen Ostrick,Debra Morris,Matthew Vincent,Eddy Anglade,Lucian V. Del Priore,Robert Lanza +17 more
Reads0
Chats0
TLDR
The results suggest that hESC-derived cells could provide a potentially safe new source of cells for the treatment of various unmet medical disorders requiring tissue repair or replacement.About:
This article is published in The Lancet.The article was published on 2015-02-07. It has received 990 citations till now. The article focuses on the topics: Macular dystrophy & Stargardt disease.read more
Citations
More filters
Journal ArticleDOI
Stem cell based therapies for age-related macular degeneration: The promises and the challenges
Hossein Nazari,Li Zhang,Danhong Zhu,Gerald J. Chader,Paulo Falabella,Francisco Rosa Stefanini,Teisha J. Rowland,Dennis O. Clegg,Amir H. Kashani,David R. Hinton,Mark S. Humayun +10 more
TL;DR: Changing dead or dysfunctional RPE with healthy RPE has been shown to rescue dying photoreceptors and improve vision in animal models of retinal degeneration and possibly in AMD patients, and methods to generate stem cell-derived RPE, immune reaction against such cells, and approaches to deliver desired cells into the eye will be explored.
Journal ArticleDOI
Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors
Anai Gonzalez-Cordero,Kamil Kruczek,Arifa Naeem,Milan Fernando,Magdalena Kloc,Joana Ribeiro,Debbie Goh,Yanai Duran,Samuel J.I. Blackford,Laura Abelleira-Hervas,Robert D. Sampson,Ian O. Shum,Matthew J. Branch,Peter Gardner,Jane C. Sowden,James W B Bainbridge,Alexander J. Smith,Emma L. West,Rachael A. Pearson,Robin R. Ali,Robin R. Ali +20 more
TL;DR: A modified 2D/3D protocol is reported for generating hPSC-derived neural retinal vesicles with well-formed ONL-like structures containing cones and rods bearing inner segments and connecting cilia, nascent outer segments, and presynaptic structures that recapitulates human photoreceptor development, allowing the isolation and transplantation of a pure population of stage-matched cones.
Journal ArticleDOI
Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells in macular degeneration
Manjit S Mehat,Venki Sundaram,Caterina Ripamonti,Anthony G. Robson,Alexander J. Smith,Shyamanga Borooah,Martha Robinson,Adam N. Rosenthal,William Innes,Richard G. Weleber,Richard W J Lee,Michael D. Crossland,Gary S. Rubin,Baljean Dhillon,David H. W. Steel,Eddy Anglade,Robert Lanza,Robin R. Ali,Michel Michaelides,James W B Bainbridge +19 more
TL;DR: Subretinal hyperpigmentation is consistent with the survival of viable transplanted hESC-derived RPE cells, but may reflect released pigment in their absence, and intervention in early stage of disease should be approached with caution.
Journal ArticleDOI
Influence of donor age on induced pluripotent stem cells
Valentina Lo Sardo,William S. Ferguson,Galina Erikson,Eric J. Topol,Kristin K. Baldwin,Ali Torkamani +5 more
TL;DR: It is established that donor age is associated with an increased risk of abnormalities in iPSCs and will inform clinical development of reprogramming technology.
Journal ArticleDOI
Adaptive optics ophthalmoscopy
Austin Roorda,Jacque L. Duncan +1 more
TL;DR: This review starts with a brief history and description of adaptive optics (AO) technology, followed by a showcase of the latest capabilities of AO systems for imaging the human retina and an extensive review of the literature on where AO is being used clinically.
References
More filters
Journal ArticleDOI
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
Journal ArticleDOI
Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
Journal ArticleDOI
Establishment in culture of pluripotential cells from mouse embryos
TL;DR: The establishment in tissue culture of pluripotent cell lines which have been isolated directly from in vitro cultures of mouse blastocysts are reported, able to differentiate either in vitro or after innoculation into a mouse as a tumour in vivo.
Journal ArticleDOI
The Retinal Pigment Epithelium in Visual Function
TL;DR: This review summarizes the current knowledge of RPE functions and describes how failure of these functions causes loss of visual function.
Journal ArticleDOI
Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
Albert M. Maguire,Francesca Simonelli,Eric A. Pierce,Edward N. Pugh,Federico Mingozzi,Jeannette L. Bennicelli,Sandro Banfi,Kathleen A. Marshall,Francesco Testa,Enrico Maria Surace,Settimio Rossi,Arkady Lyubarsky,Valder R. Arruda,Barbara A. Konkle,Edwin M. Stone,Edwin M. Stone,Junwei Sun,Jonathan B. Jacobs,L. F. Dell'Osso,Richard W. Hertle,Jian Xing Ma,T. Michael Redmond,Xiaosong Zhu,Bernd Hauck,Olga Zelenaia,Kenneth S. Shindler,Maureen G. Maguire,J. Fraser Wright,Nicholas J. Volpe,Jennifer Wellman McDonnell,Alberto Auricchio,Katherine A. High,Katherine A. High,Jean Bennett +33 more
TL;DR: This study investigated the safety of subretinal delivery of a recombinant adeno-associated virus (AAV) carrying RPE65 complementary DNA (cDNA) and found three patients with LCA2 had an acceptable local and systemic adverse-event profile after delivery of AAV2.hRPE65v2.
Related Papers (5)
Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
Michiko Mandai,Akira Watanabe,Yasuo Kurimoto,Yasuhiko Hirami,Chikako Morinaga,Takashi Daimon,Masashi Fujihara,Hiroshi Akimaru,Noriko Sakai,Yumiko Shibata,Motoki Terada,Yui Nomiya,Shigeki Tanishima,Masahiro Nakamura,Hiroyuki Kamao,Sunao Sugita,Akishi Onishi,Tomoko Ito,Kanako Fujita,Shin Kawamata,Masahiro J. Go,Chikara Shinohara,Kenichiro Hata,Masanori Sawada,Midori Yamamoto,Sachiko Ohta,Yasuo Ohara,Kenichi Yoshida,Junko Kuwahara,Yuko Kitano,Naoki Amano,Masafumi Umekage,Fumiyo Kitaoka,Azusa Tanaka,Chihiro Okada,Naoko Takasu,Seishi Ogawa,Shinya Yamanaka,Masayo Takahashi +38 more