Journal ArticleDOI
Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies
Steven D. Schwartz,Carl D. Regillo,Byron L. Lam,Dean Eliott,Philip J. Rosenfeld,Ninel Z. Gregori,Jean-Pierre Hubschman,Janet L. Davis,Gad Heilwell,Marc J. Spirn,Joseph I. Maguire,Jane Bateman,Rosaleen Ostrick,Debra Morris,Matthew Vincent,Eddy Anglade,Lucian V. Del Priore,Robert Lanza +17 more
TLDR
The results suggest that hESC-derived cells could provide a potentially safe new source of cells for the treatment of various unmet medical disorders requiring tissue repair or replacement.About:
This article is published in The Lancet.The article was published on 2015-02-07. It has received 990 citations till now. The article focuses on the topics: Macular dystrophy & Stargardt disease.read more
Citations
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Journal ArticleDOI
Sensory Transduction in Photoreceptors and Olfactory Sensory Neurons: Common Features and Distinct Characteristics.
TL;DR: In this article, a review summarizes some of the common and unique features of photoreceptors and olfactory sensory neurons that make these cells so exciting to study, and how diseases affect our senses of vision and smell.
Journal ArticleDOI
Emerging treatments for geographic atrophy in age-related macular degeneration.
TL;DR: There are promising new treatments to prevent GA progression as well as some that may reverse the disease course as discussed by the authors, however, the progress in understanding the disease pathophysiology and clinical trial data is reviewed.
Journal ArticleDOI
The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies
Lei Wang,Wei Wu,Qi Gu,Zengping Liu,Qiyou Li,Zhongwen Li,Jinhui Fang,Wenjing Liu,Jun Wu,Ying Zhang,Liu Wang,Haiwei Xu,Wei Li,Baoyang Hu,Qi Zhou,Zhengqin Yin,Jie Hao +16 more
TL;DR: Comparing the RPE cells suspensions and cell sheet transplantation using a wellknown model of dry AMD, Royal College of Surgeons (RCS) rats and the comparison between these two strategies should be well studied to maximize the effects of RPE transplantation is compared.
Journal ArticleDOI
Human Amniotic Epithelial Stem Cell-Derived Retinal Pigment Epithelium Cells Repair Retinal Degeneration.
Li Jinying,Li Jinying,Chen Qiu,Chen Qiu,Yang Wei,Weixin Yuan,Jia Liu,Jia Liu,Wenyu Cui,Wenyu Cui,Jiayi Zhou,Jiayi Zhou,Cong Qiu,Cong Qiu,Li-He Guo,Liquan Huang,Zhen Ge,Yu Luyang,Yu Luyang +18 more
TL;DR: In this article, a high-efficient, low-cost and safety-guaranteed system for generating functional RPE cells from human amniotic epithelial stem cells (hAESCs) was proposed.
Book ChapterDOI
Small Molecules: Controlling Cell Fate and Function
Baisong Lu,Anthony Atala +1 more
TL;DR: In vitro and in vivo applications of small molecules in regenerative medicine include in Vitro regulating pluripotent stem cell and adult stem cell production and differentiation, in vivo modulation of adult stem cells and differentiated cells, and changing cell fate to restore the missing cells.
References
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
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Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
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Establishment in culture of pluripotential cells from mouse embryos
TL;DR: The establishment in tissue culture of pluripotent cell lines which have been isolated directly from in vitro cultures of mouse blastocysts are reported, able to differentiate either in vitro or after innoculation into a mouse as a tumour in vivo.
Journal ArticleDOI
The Retinal Pigment Epithelium in Visual Function
TL;DR: This review summarizes the current knowledge of RPE functions and describes how failure of these functions causes loss of visual function.
Journal ArticleDOI
Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
Albert M. Maguire,Francesca Simonelli,Eric A. Pierce,Edward N. Pugh,Federico Mingozzi,Jeannette L. Bennicelli,Sandro Banfi,Kathleen A. Marshall,Francesco Testa,Enrico Maria Surace,Settimio Rossi,Arkady Lyubarsky,Valder R. Arruda,Barbara A. Konkle,Edwin M. Stone,Edwin M. Stone,Junwei Sun,Jonathan B. Jacobs,L. F. Dell'Osso,Richard W. Hertle,Jian Xing Ma,T. Michael Redmond,Xiaosong Zhu,Bernd Hauck,Olga Zelenaia,Kenneth S. Shindler,Maureen G. Maguire,J. Fraser Wright,Nicholas J. Volpe,Jennifer Wellman McDonnell,Alberto Auricchio,Katherine A. High,Katherine A. High,Jean Bennett +33 more
TL;DR: This study investigated the safety of subretinal delivery of a recombinant adeno-associated virus (AAV) carrying RPE65 complementary DNA (cDNA) and found three patients with LCA2 had an acceptable local and systemic adverse-event profile after delivery of AAV2.hRPE65v2.
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