Journal ArticleDOI
Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies
Steven D. Schwartz,Carl D. Regillo,Byron L. Lam,Dean Eliott,Philip J. Rosenfeld,Ninel Z. Gregori,Jean-Pierre Hubschman,Janet L. Davis,Gad Heilwell,Marc J. Spirn,Joseph I. Maguire,Jane Bateman,Rosaleen Ostrick,Debra Morris,Matthew Vincent,Eddy Anglade,Lucian V. Del Priore,Robert Lanza +17 more
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TLDR
The results suggest that hESC-derived cells could provide a potentially safe new source of cells for the treatment of various unmet medical disorders requiring tissue repair or replacement.About:
This article is published in The Lancet.The article was published on 2015-02-07. It has received 990 citations till now. The article focuses on the topics: Macular dystrophy & Stargardt disease.read more
Citations
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Journal ArticleDOI
Analysis of the results of transplantation of the retinal pigment epithelium in the experiment
N. V. Neroeva,Maria A. Lagarkova,Lyudmila A. Katargina,N. S. Izmailova,Pavel Andreevich Ilyukhin,O.A. Utkina +5 more
TL;DR: In this article , the results of cell transplantation in the form of a cell suspension into the subretinal space at various times were analyzed and it was found that the injected cells retained their viability for up to 8 months.
Proceedings ArticleDOI
Automatic Pretreatment for In-Situ Cryopreservation of Single Stem Cells Based on Microfluidic Droplet Manipulatio
TL;DR: In this paper, an automatic cryopreservation pretreatment method using planar microfluidic chips with super-hydrophobic surfaces was proposed to reduce the risks of cell damage, contamination, loss and osmotic shock caused by manual operations.
Journal ArticleDOI
Future perspective of stem cell-derived exosomes: Cell-free therapeutic strategies for retinal degeneration
TL;DR: In this paper , a review depicts the molecular mechanisms underlying exosome-based therapy, especially in retina degeneration diseases, and the use of stem cell-derived exosomes could be considered a novel and cell-free therapeutic strategy in regenerative medicine.
Peer Review
Transplantasi human embryonic stem cell retinal pigment epithelium subretinal sebagai terapi degenerasi makula terkait usia tipe kering
Muhammad Thifan Satyagraha,Andhwika Afif Fahrezi,Rafi Annisa Ulum,Gibran,Chandra Syarif Hidayatullah +4 more
TL;DR: Subretinal hESC-RPE transplantation can improve eye acuity in dry-type AMD patients through increased pigmentation and its safety and tolerability have been proven with no abnormal proliferation or immune response found.
Book ChapterDOI
Stem Cells in Regenerative Medicine: Clinical Trials
TL;DR: Although embryonic stem cells (ESCs) are considered a potential source of stem cells, due to ethical concerns, there is not much progress in using ESCs in clinical conditions as mentioned in this paper.
References
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
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Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
Journal ArticleDOI
Establishment in culture of pluripotential cells from mouse embryos
TL;DR: The establishment in tissue culture of pluripotent cell lines which have been isolated directly from in vitro cultures of mouse blastocysts are reported, able to differentiate either in vitro or after innoculation into a mouse as a tumour in vivo.
Journal ArticleDOI
The Retinal Pigment Epithelium in Visual Function
TL;DR: This review summarizes the current knowledge of RPE functions and describes how failure of these functions causes loss of visual function.
Journal ArticleDOI
Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
Albert M. Maguire,Francesca Simonelli,Eric A. Pierce,Edward N. Pugh,Federico Mingozzi,Jeannette L. Bennicelli,Sandro Banfi,Kathleen A. Marshall,Francesco Testa,Enrico Maria Surace,Settimio Rossi,Arkady Lyubarsky,Valder R. Arruda,Barbara A. Konkle,Edwin M. Stone,Edwin M. Stone,Junwei Sun,Jonathan B. Jacobs,L. F. Dell'Osso,Richard W. Hertle,Jian Xing Ma,T. Michael Redmond,Xiaosong Zhu,Bernd Hauck,Olga Zelenaia,Kenneth S. Shindler,Maureen G. Maguire,J. Fraser Wright,Nicholas J. Volpe,Jennifer Wellman McDonnell,Alberto Auricchio,Katherine A. High,Katherine A. High,Jean Bennett +33 more
TL;DR: This study investigated the safety of subretinal delivery of a recombinant adeno-associated virus (AAV) carrying RPE65 complementary DNA (cDNA) and found three patients with LCA2 had an acceptable local and systemic adverse-event profile after delivery of AAV2.hRPE65v2.
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