IL-17 and IL-22 in immunity: Driving protection and pathology.
TLDR
This review highlights recent understandings in cellular sources, signaling mechanisms, physiologic as well as pathogenic role of the double‐faceted cytokines IL‐17 and IL‐22.Abstract:
IL-17 and IL-22 are tissue-signaling cytokines that favor protection and regeneration of barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share cellular sources, signaling pathways, and functional aspects; however, taking a closer look they differ, e.g. in their pro-inflammatory or regenerative potential. An imbalance of the carefully orchestrated tissue-signaling system might result in autoimmune diseases, promote cancer growth, or predispose to infectious diseases. This review highlights recent understandings in cellular sources, signaling mechanisms, physiologic as well as pathogenic role of the double-faceted cytokines IL-17 and IL-22.read more
Citations
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Homeostatic Immunity and the Microbiota
TL;DR: The dominant cellular mediators of these interactions are reviewed and emerging themes associated with the current understanding of the homeostatic immunological dialogue between the host and its microbiota are discussed.
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A guiding map for inflammation
Mihai G. Netea,Frances R. Balkwill,Michel Chonchol,Fabio Cominelli,Marc Y. Donath,Evangelos J. Giamarellos-Bourboulis,Douglas T. Golenbock,Mark S. Gresnigt,Michael T. Heneka,Michael T. Heneka,Hal M. Hoffman,Richard S. Hotchkiss,Leo A. B. Joosten,Leo A. B. Joosten,Daniel L. Kastner,Martin Korte,Eicke Latz,Eicke Latz,Eicke Latz,Peter Libby,Thomas Mandrup-Poulsen,Alberto Mantovani,Kingston H. G. Mills,Kristen L. Nowak,Luke A. J. O'Neill,Peter Pickkers,Tom van der Poll,Paul M. Ridker,Joost Schalkwijk,David A. Schwartz,Britta Siegmund,Clifford J. Steer,Herbert Tilg,Jos W. M. van der Meer,Frank L. van de Veerdonk,Charles A. Dinarello,Charles A. Dinarello +36 more
TL;DR: A general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues is provided.
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Skin Acute Wound Healing: A Comprehensive Review
TL;DR: This review provides present day information regarding the status of the participant cells, extracellular matrix, cytokines, chemokines, and growth factors, as well as their interactions with the microenvironment during the wound healing process.
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The biology and functional importance of MAIT cells.
Dale I. Godfrey,Hui-Fern Koay,Hui-Fern Koay,James McCluskey,Nicholas A Gherardin,Nicholas A Gherardin +5 more
TL;DR: Evidence showing that MAIT cells are a key component of the immune system is reviewed and their basic biology, development, role in disease and immunotherapeutic potential is discussed.
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The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond
TL;DR: The current knowledge around the cytokines belonging to the IL-17 family in relation to skin inflammation in general and psoriasis in particular is summarized, possible clinical implications are discussed, and a comprehensive understanding of the different roles played by theIL-17 cytokines are discussed.
References
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TL;DR: This study has demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in theBritish population is generally modest.
Journal ArticleDOI
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Estelle Bettelli,Yijun Carrier,Wenda Gao,Thomas Korn,Terry B. Strom,Mohamed Oukka,Howard L. Weiner,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6, an acute phase protein induced during inflammation, completely inhibits the generation of Foxp3+ Treg cells induced by TGF-β, and the data demonstrate a dichotomy in thegeneration of pathogenic (TH17) T cells that induce autoimmunity and regulatory (Foxp3+) T Cells that inhibit autoimmune tissue injury.
Journal ArticleDOI
IL-17 and Th17 Cells.
TL;DR: The investigation of the differentiation, effector function, and regulation of Th17 cells has opened up a new framework for understanding T cell differentiation and now appreciate the importance of Th 17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease.
Journal ArticleDOI
STATs in cancer inflammation and immunity: a leading role for STAT3
TL;DR: Signal transducer and activator of transcription proteins are central in determining whether immune responses in the tumour microenvironment promote or inhibit cancer, and STAT3 is a promising target to redirect inflammation for cancer therapy.
Journal ArticleDOI
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.
Liang Zhou,Ivaylo I. Ivanov,Rosanne Spolski,Roy Min,Kevin Shenderov,Takeshi Egawa,David E. Levy,Warren J. Leonard,Dan R. Littman +8 more
TL;DR: IL-6 orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-β, amplify RORγt-dependent differentiation of TH-17 cells.