Journal ArticleDOI
IL-6 and IGF-1 are independent prognostic factors of liver steatosis and non-alcoholic steatohepatitis in morbidly obese patients.
David Garcia-Galiano,Miguel A. Sánchez-Garrido,Isabel Espejo,José Luis Montero,G. Costán,Trinidad Marchal,Antonio Membrives,José María Gallardo-Valverde,Juan R. Muñoz-Castañeda,Eugenio Arévalo,Manuel de la Mata,Jordi Muntané +11 more
Reads0
Chats0
TLDR
The concentration of glucose, insulin, IL-6 and IGF-1 in blood are useful markers for the selection of patients with liver steatosis or NASH in morbidly obese patients.Abstract:
Lipid accumulation and other histological liver markers characterize patients with non-alcoholic steatohepatitis (NASH). The identification of non-invasive prognostic factors of liver steatosis and NASH are relevant for the unravelling of the mechanisms of this disease, as well as for the clinical diagnoses of these patients. 36 patients with morbid obesity and 12 healthy subjects were consecutively enrolled in this cross-sectional study to determine the serological parameters associated with the degree of hepatic steatosis and NASH. Clinical, biochemical and histologic variables were examined in blood and liver biopsies by descriptive, univariate and multivariate regression analysis. The patients were distributed as non-NASH (14), probably-NASH (13) and NASH (9), according to the Non-alcoholic fatty liver disease Activity Score (NAS). The study identified remarkable differences in liver steatosis, and glucose, insulin, IL-6 and IGF-1 concentrations in blood among patients with morbid obesity. IL-6 was correlated with the degree of liver steatosis until the morbidly obese patients fulfil the criteria of NASH. The patients with NASH reduced IL-6 concentration in blood. IGF-1 decreased throughout the progression of NASH. TNF-α concentration was not related to liver steatosis or NASH in morbidly obese patients.The multivariate regression analysis identified glucose >110 mg/dL, IL-6 >4.81 pg/mL and IGF-1 4.5 and IGF-1 <110 ng/mL as independent predictors of hepatic steatosis and NASH, respectively. The concentration of glucose, insulin, IL-6 and IGF-1 in blood are useful markers for the selection of patients with liver steatosis or NASH.read more
Citations
More filters
Journal ArticleDOI
DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery
M Ahrens,Ole Ammerpohl,Witigo von Schönfels,Julia Kolarova,Susanne Bens,Timo Itzel,Andreas Teufel,A Herrmann,Mario Brosch,Holger Hinrichsen,Wiebke Erhart,Jan Hendrik Egberts,Bence Sipos,Stefan Schreiber,Robert Häsler,Felix Stickel,Thomas Becker,Michael Krawczak,Christoph Röcken,Reiner Siebert,Clemens Schafmayer,Jochen Hampe +21 more
TL;DR: Liver samples from morbidly obese patients with all stages of NAFLD and controls were analyzed by array-based DNA methylation and mRNA expression profiling, providing an example of treatment-induced epigenetic organ remodeling in humans.
Journal ArticleDOI
A novel diagnostic biomarker panel for obesity-related nonalcoholic steatohepatitis (NASH).
Zobair M. Younossi,Zobair M. Younossi,Zobair M. Younossi,Mohammed Jarrar,Mohammed Jarrar,Clare Nugent,Clare Nugent,Manpreet Randhawa,Manpreet Randhawa,Mariam Afendy,Mariam Afendy,Maria Stepanova,Maria Stepanova,Nila Rafiq,Nila Rafiq,Zachary Goodman,Vikas Chandhoke,Vikas Chandhoke,Ancha Baranova,Ancha Baranova,Ancha Baranova +20 more
TL;DR: Four ELISA-based tests were combined to form a simple diagnostic biomarker for NASH and blinded validation of this model confirmed its reliability for separating NASH from simple steatosis.
Journal ArticleDOI
Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease
TL;DR: The role of adipocytokines and proinflammatory cytokines in the pathogenesis of NAFLD is explored, particularly on adiponectin, leptin and ghrelin, with a brief mention of resistin, visfatin and retinol-binding protein 4 among adipokines, and tumor necrosis factor-α, interleukin (IL)-6, IL-1, and briefly IL-18 among pro inflammatory cytokines.
Journal ArticleDOI
Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery.
Henrike Sell,Adeline Divoux,Adeline Divoux,Christine Poitou,Arnaud Basdevant,Jean-Luc Bouillot,Jean-Luc Bouillot,Pierre Bedossa,Pierre Bedossa,Joan Tordjman,Jürgen Eckel,Karine Clément +11 more
TL;DR: It is suggested that chemerin might mediate metabolic alterations in obesity, drastically improving after gastric bypass, and correlated with insulin resistance and markers of liver pathology.
Journal ArticleDOI
Diabetes and nonalcoholic Fatty liver disease: a pathogenic duo.
Kathryn Williams,Kathryn Williams,Nicholas A. Shackel,Nicholas A. Shackel,Mark D. Gorrell,Mark D. Gorrell,Susan V. McLennan,Susan V. McLennan,Stephen M. Twigg,Stephen M. Twigg +9 more
TL;DR: The pathogenic links between NAFLD and diabetes are examined by exploring the epidemiological evidence in humans and also through newer animal models, and the potential role of preventive and therapeutic approaches in the setting of diabetes is examined.
References
More filters
Journal ArticleDOI
Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
TL;DR: The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Inflammation, stress, and diabetes
TL;DR: The molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to diabetes are discussed.
Journal ArticleDOI
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
Journal ArticleDOI
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
Christi A. Matteoni,Zobair M. Younossi,Terry Gramlich,Navdeep Boparai,Yao Chang Liu,Arthur J. McCullough +5 more
TL;DR: The outcome of cirrhosis and liver-related death is not uniform across the spectrum of nonalcoholic fatty liver, and poor outcomes are more frequent in patients in whom biopsies show ballooning degeneration and Mallory hyaline or fibrosis.