Intestinal stem cell function in Drosophila and mice.
Huaqi Jiang,Bruce A. Edgar +1 more
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TLDR
Recent genetic studies of stem cell-mediated homeostatic growth in the Drosophila midgut and the mouse small intestine are reviewed, highlighting similarities and differences in the mechanisms that control stem cell proliferation and differentiation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 2012-08-01 and is currently open access. It has received 144 citations till now. The article focuses on the topics: Stem cell & Adult stem cell.read more
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Reparative inflammation takes charge of tissue regeneration
Michael Karin,Hans Clevers +1 more
TL;DR: Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair, indicating that it is an evolutionarily important process.
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Conservation of transcription factor binding specificities across 600 million years of bilateria evolution
Kazuhiro R. Nitta,Arttu Jolma,Yimeng Yin,Ekaterina Morgunova,Teemu Kivioja,Junaid Akhtar,Korneel Hens,Jarkko Toivonen,Bart Deplancke,Eileen E. M. Furlong,Jussi Taipale +10 more
TL;DR: This analysis revealed that TF binding specificities are highly conserved between Drosophila and mammals, and that for orthologous TFs, the similarity extends even to the level of very subtle dinucleotide binding preferences.
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Drosophila melanogaster : a model and a tool to investigate malignancy and identify new therapeutics
TL;DR: Lower-model organisms such as Drosophila melanogaster strains that are engineered to recapitulate key aspects of specific types of human cancer have been paving the way for the future role of this 'workhorse' of biomedical research, helping to further investigate the process of malignancy, and serving as platforms for therapeutic drug discovery.
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Fly-FUCCI: A Versatile Tool for Studying Cell Proliferation in Complex Tissues
Norman Zielke,Jerome Korzelius,Monique van Straaten,Katharina Bender,Gregor F.P. Schuhknecht,Devanjali Dutta,Jinyi Xiang,Bruce A. Edgar +7 more
TL;DR: The development of a Drosophila-specific FUCCI system (Fly-FUCCI) that allows one to distinguish G1, S, and G2 phases of interphase and should be a valuable tool for visualizing cell-cycle activity during development, tissue homeostasis, and neoplastic growth.
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Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.
John C. Schell,Dona R. Wisidagama,Claire L. Bensard,Helong Zhao,Peng Wei,Jason M. Tanner,Aimee Flores,Jeffrey Mohlman,Lise K. Sorensen,Christian S. Earl,Kristofor A. Olson,Ren Miao,T. Cameron Waller,Don A. Delker,Priyanka Kanth,Lei Jiang,Lei Jiang,Ralph J. DeBerardinis,Mary P. Bronner,Dean Y. Li,James E. Cox,Heather R. Christofk,William E. Lowry,Carl S. Thummel,Jared Rutter +24 more
TL;DR: It is demonstrated that limiting mitochondrial pyruvate metabolism is necessary and sufficient to maintain the proliferation of intestinal stem cells and to understand the role this transition from glycolysis to pyruVate oxidation plays in stem cell maintenance and differentiation.
References
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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Toshiro Sato,Robert G.J. Vries,Hugo J. Snippert,Marc van de Wetering,Nick Barker,Daniel E. Stange,Johan H. van Es,Arie Abo,Pekka Kujala,Peter J. Peters,Hans Clevers +10 more
TL;DR: It is concluded that intestinal cryptvillus units are self-organizing structures, which can be built from a single stem cell in the absence of a non-epithelial cellular niche.
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Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.
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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Toshiro Sato,Johan H. van Es,Hugo J. Snippert,Daniel E. Stange,Robert G.J. Vries,Maaike van den Born,Nick Barker,Noah F. Shroyer,Marc van de Wetering,Hans Clevers +9 more
TL;DR: It is concluded that Lgr5 stem cells compete for essential niche signals provided by a specialized daughter cell, the Paneth cell, in colon crypts, and co-culturing of sorted stem cells with Paneth cells markedly improves organoid formation.
Journal ArticleDOI
IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
Sergei I. Grivennikov,Eliad Karin,Janoš Terzić,Janoš Terzić,Daniel Mucida,Guann-Yi Yu,Sivakumar Vallabhapurapu,Jürgen Scheller,Stefan Rose-John,Hilde Cheroutre,Lars Eckmann,Michael Karin +11 more
TL;DR: It is demonstrated that IL-6 is a critical tumor promoter during early CAC tumorigenesis and the NF-kappaB-IL-6-Stat3 cascade is an important regulator of the proliferation and survival of tumor-initiating IECs.