Investigating the Internalization and COVID-19 Antiviral Computational Analysis of Optimized Nanoscale Zinc Oxide
Mohamed Hamdi,Hend Mohamed Abdel-Bar,Enas Elmowafy,Ahmed El-Khouly,Ahmed El-Khouly,Mai Mansour,Gehanne A.S. Awad +6 more
- Vol. 6, Iss: 10, pp 6848-6860
TLDR
In this article, a nanoscale zinc oxide (ZnO) nanoparticles (NPs) were fabricated and relevant aspects related to the formulation such as optimization, structure, purity, and morphology were elucidated.Abstract:
Global trials are grappling toward identifying prosperous remediation against the ever-emerging and re-emerging pathogenic respiratory viruses. Battling coronavirus, as a model respiratory virus, via repurposing existing therapeutic agents could be a welcome move. Motivated by its well-demonstrated curative use in herpes simplex and influenza viruses, utilization of the nanoscale zinc oxide (ZnO) would be an auspicious approach. In this direction, ZnO nanoparticles (NPs) were fabricated herein and relevant aspects related to the formulation such as optimization, structure, purity, and morphology were elucidated. In silico molecular docking was conducted to speculate the possible interaction between ZnO NPs and COVID-19 targets including the ACE2 receptor, COVID-19 RNA-dependent RNA polymerase, and main protease. The cellular internalization of ZnO NPs using human lung fibroblast cells was also assessed. Optimized hexagonal and spherical ZnO nanostructures of a crystallite size of 11.50 ± 0.71 nm and positive charge were attained. The pure and characteristic hexagonal wurtzite P63mc crystal structure was also observed. Interestingly, felicitous binding of ZnO NPs with the three tested COVID-19 targets, via hydrogen bond formation, was detected. Furthermore, an enhanced dose-dependent cellular uptake was demonstrated. The obtained results infer a rationale, awaiting validation from further biological and therapeutic studies.read more
Citations
More filters
Journal ArticleDOI
Metal oxide nanoparticles for safe active and intelligent food packaging
TL;DR: In this paper, a review of current innovative synthesis methods for obtaining metal oxide nanoparticles and current incorporation techniques used to obtain smart (active and/or intelligent) packaging, focusing on bio-nanocomposites, commonly used metal oxides and future mixed metal or doped metal oxide.
Journal ArticleDOI
Photocatalytic TiO2 nanomaterials as potential antimicrobial and antiviral agents: Scope against blocking the SARS-COV-2 spread
TL;DR: In this article , the authors highlight the effective disinfection of SARS-CoV-2 using TiO2 photocatalysts and discuss their potential to combat with SARS CoV2 viral infection and are promising for any other such variants or viruses, bacteria in future studies.
Journal ArticleDOI
Zinc associated nanomaterials and their intervention in emerging respiratory viruses: Journey to the field of biomedicine and biomaterials
Citlaly Gutiérrez Rodelo,Rafael A. Salinas,Erika Armenta Jaime,Silvia Armenta,Andrés Galdámez-Martínez,Silvia E. Castillo-Blum,Horacio Astudillo-de la Vega,Andrews Nirmala Grace,Carlos A. Aguilar-Salinas,Juliana Gutiérrez Rodelo,Graham Christie,Walaa F. Alsanie,Guillermo Santana,Vijay Kumar Thakur,A. Dutt +14 more
TL;DR: In this paper , the state of the art of Zn-based nanostructures are discussed in detail, and the properties of these nanomaterials as supplements for reducing viral activity and the recovery of infected patients are illustrated.
Journal ArticleDOI
Metal and metal oxide-based antiviral nanoparticles: Properties, mechanisms of action, and applications.
TL;DR: In this paper , the authors provide an overview of the design, preparation, and characterization of metal-based nanoparticles and discuss their potential mechanisms of action against various kinds of viruses.
Journal ArticleDOI
On the Efficacy of ZnO Nanostructures against SARS-CoV-2
Maria Chiara Sportelli,Margherita Izzi,Daniela Loconsole,Anna Sallustio,Rosaria Anna Picca,Roberto Felici,Maria Chironna,Nicola Cioffi +7 more
TL;DR: ZnO nanoparticles were produced using an ecofriendly method and fully characterized; their antiviral activity was tested in vitro against SARS-CoV-2, showing a decrease in viral load between 70% and 90%, as a function of the material’s composition.
References
More filters
Journal ArticleDOI
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
Journal ArticleDOI
VESTA 3 for three-dimensional visualization of crystal, volumetric and morphology data
Koichi Momma,Fujio Izumi +1 more
TL;DR: VESTA has been upgraded to the latest version, VESTA 3, implementing new features including drawing the external morphology of crystals, and an extended bond-search algorithm to enable more sophisticated searches in complex molecules and cage-like structures.
Journal ArticleDOI
Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties.
Tian Xia,Michael Kovochich,Monty Liong,Lutz Mädler,Lutz Mädler,Benjamin Gilbert,Haibin Shi,Joanne I. Yeh,Jeffrey I. Zink,Andre E. Nel +9 more
TL;DR: The results demonstrate that metal oxide nanoparticles induce a range of biological responses that vary from cytotoxic to cytoprotective and can only be properly understood by using a tiered test strategy such as that developed for oxidative stress and adapted to study other aspects of nanoparticle toxicity.
Journal ArticleDOI
The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction.
TL;DR: The effects of nanoparticle size on cellular interaction and in vivo pharmacokinetics, including cellular uptake, biodistribution and circulation half-life of nanoparticles are reviewed.
Related Papers (2)
Zinc2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro.
Love Panchariya,Wajahat Ali Khan,Shobhan Kuila,Kirtishila Sonkar,Sibasis Sahoo,Archita Ghoshal,Ankit Kumar,Dileep Kumar Verma,Abdul Hasan,Mohd Azeem Khan,Niyati Jain,Amit Kumar Mohapatra,Shubhashis Das,Jitendra K. Thakur,Souvik Maiti,Souvik Maiti,Ranjan Kumar Nanda,Rajkumar Halder,Sujatha Sunil,A. Arockiasamy +19 more
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Sebastian Günther,P. Reinke,Yaiza Fernández-García,J. Lieske,Thomas J. Lane,Helen M. Ginn,Faisal Hammad Mekky Koua,Christiane Ehrt,W. Ewert,Dominik Oberthuer,Oleksandr Yefanov,S. Meier,Kristina Lorenzen,Boris Krichel,Janine-Denise Kopicki,Luca Gelisio,W. Brehm,Ilona Dunkel,B. Seychell,Henry Gieseler,Brenna Norton-Baker,Brenna Norton-Baker,Beatriz Escudero-Pérez,M. Domaracky,S. Saouane,A. Tolstikova,Thomas A. White,Anna Hänle,M. Groessler,Holger Fleckenstein,F. Trost,M. Galchenkova,Y. Gevorkov,Chufeng Li,Salah Awel,Ariana Peck,Miriam Barthelmess,Frank Schlünzen,P. Lourdu Xavier,N. Werner,H. Andaleeb,N. Ullah,Sven Falke,Vasundara Srinivasan,Bruno Alves Franca,M. Schwinzer,Hévila Brognaro,Cromarte Rogers,D. Melo,Joanna J. Zaitseva-Doyle,Juraj Knoska,Gisel E. Peña-Murillo,Aida Rahmani Mashhour,V. Hennicke,Pontus Fischer,Johanna Hakanpää,Jan Meyer,Philip Gribbon,Bernhard Ellinger,Maria Kuzikov,Markus Wolf,Andrea R. Beccari,Gleb Bourenkov,David von Stetten,Guillaume Pompidor,Isabel Bento,Saravanan Panneerselvam,Ivars Karpics,Thomas R. Schneider,Maria Garcia-Alai,Stephan Niebling,Christian M. Günther,C. Schmidt,Robin Schubert,Huijong Han,J. Boger,Diana C. F. Monteiro,Linlin Zhang,Xinyuanyuan Sun,J. Pletzer-Zelgert,J. Wollenhaupt,Christian G. Feiler,Manfred S. Weiss,Eike C. Schulz,Pedram Mehrabi,Katarina Karničar,Aleksandra Usenik,Jure Loboda,Henning Tidow,Ashwin Chari,Rolf Hilgenfeld,Charlotte Uetrecht,Russell J. Cox,Andrea Zaliani,Tobias Beck,Matthias Rarey,Stephan Günther,Dušan Turk,Winfried Hinrichs,Winfried Hinrichs,Henry N. Chapman,Arwen R. Pearson,Christian Betzel,Alke Meents +103 more