Journal ArticleDOI
Late endosomes derive from early endosomes by maturation
Willem Stoorvogel,Ger J. Strous,Hans J. Geuze,Viola Oorschot,Alan L. Schwartzt,Alan L. Schwartzt +5 more
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TLDR
A model in which early endosomes gradually mature into late endosomal hydrolases is supported, in whichearly endocytosed proteins destined for degradation in lysosomes are targeted mainly to early endOSomes following uptake.About:
This article is published in Cell.The article was published on 1991-05-03. It has received 305 citations till now. The article focuses on the topics: Endosome & Endocytic cycle.read more
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Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
TL;DR: Exosomes were described as vesicles of endosomal origin secreted from reticulocytes in the 1980s as discussed by the authors, and their biogenesis, their secretion, and their subsequent fate are discussed, as their functions rely on these important processes.
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other
TL;DR: The definition of exosomes and other secreted extracellular vesicles, which mediating intercellular communication between different cell types in the body, and thus affecting normal and pathological conditions are focused on.
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Rab Conversion as a Mechanism of Progression from Early to Late Endosomes
TL;DR: This work found that the level of Rab 5 dynamically fluctuates on individual early endosomes, linked by fusion and fission events into a network in time, and suggested Rab conversion as the mechanism of cargo progression between early and late endosome.
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Lysosomes: fusion and function
TL;DR: Lysosomes are dynamic organelles that receive and degrade macromolecules from the secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways, as well as having more specialized secretory functions in some cell types.
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Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
Paul Saftig,Judith Klumperman +1 more
TL;DR: The importance of lysosomal trafficking pathways is emphasized by recent findings that reveal new roles for lysOSomal membrane proteins in cellular physiology and in an increasing number of diseases that are characterized by defects inLysosome biogenesis.
References
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Journal ArticleDOI
Peroxidase-labeled antibody. A new method of conjugation
Paul K. Nakane,Akira Kawaoi +1 more
TL;DR: A new method of conjugating horseradish peroxidase with proteins was developed by oxidizing the carbohydrate moiety with sodium periodate and bound to free amino groups of proteins unidirectionally at high efficiencies.
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Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System
Joseph L. Goldstein,Michael S. Brown,Richard G.W. Anderson,David W. Russell,Wolfgang J. Schneider +4 more
TL;DR: This data indicates that intracellular routes in the response of the immune system to EMT are regulated by Tournaisian reprograming, a type of ‘spatially aggregating’ behaviour.
ENDOCYTOSIS: Concepts Emerging from the LDL Receptor System
Joseph L. Goldstein,Michael S. Brown,Richard G.W. Anderson,David W. Russell,Wolfgang J. Schne +4 more
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pH and the recycling of transferrin during receptor-mediated endocytosis
TL;DR: At pH 5.4 apotransferrin (iron-free transferrin) binds to cell-surface transferrin receptors to the same extent and with the same affinity as does diferric transferrin at pH 7.0.