Journal ArticleDOI
LncRNA RPPH1 attenuates Aβ25-35-induced endoplasmic reticulum stress and apoptosis in SH-SY5Y cells via miR-326/PKM2.
TLDR
Aβ25-35-induced ERS and apoptosis in SH-SY5Y cells can be attenuated by lncRNA RPPH1 through regulating miR-326/PKM2 axis, providing therapeutic options for AD patients.Abstract:
The durative endoplasmic reticulum stress (ERS) and subsequent apoptosis contributes to the development and progression of Alzheimer’s disease (AD). MiR-326 can reduce pyruvate kinase M2 (PKM2) exp...read more
Citations
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Journal ArticleDOI
Competing Endogenous RNA Networks as Biomarkers in Neurodegenerative Diseases.
Leticia Moreno-García,Tresa López-Royo,Ana C. Calvo,Janne M. Toivonen,Miriam de la Torre,Laura Moreno-Martínez,Nora Molina,Paula Aparicio,Pilar Zaragoza,Raquel Manzano,Rosario Osta +10 more
TL;DR: Although numerous studies have been carried out, further research is needed to validate these complex interactions between RNAs and the alterations in RNA editing that could provide specific ceRNET profiles for neurodegenerative disorders, paving the way to a better understanding of these diseases.
Journal ArticleDOI
The ER Stress/UPR Axis in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis.
Mahmoud Aghaei,Sanaz Dastghaib,Sajjad Aftabi,Mohamad Reza Aghanoori,Javad Alizadeh,Pooneh Mokarram,Parvaneh Mehrbod,Milad Ashrafizadeh,Ali Zarrabi,Kielan Darcy McAlinden,Mathew Suji Eapen,Sukhwinder Singh Sohal,Pawan K. Sharma,Amir A. Zeki,Saeid Ghavami +14 more
TL;DR: In this paper, the impact of both external and internal stressors on the endoplasmic reticulum (ER) in idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) was discussed.
Journal ArticleDOI
The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs.
TL;DR: Recently, a vast plethora of research has focused on identifying therapeutic strategies for targeting pyruvate kinase isoenzyme type M2 (PKM2) in various isoforms that can exhibit diverse biological functions and outcomes.
Journal ArticleDOI
Long Noncoding RNAs in Neurodegenerative Diseases: Pathogenesis and Potential Implications as Clinical Biomarkers.
Meng Zhang,Ping He,Zhi-Gang Bian +2 more
TL;DR: In this paper, a review of the role of long noncoding RNAs (lncRNAs) in the progression of neurological diseases including NDDs is presented, and the potential applicability of circulating lncRNA as biomarkers in NDD diagnostics and prognostics is discussed.
Journal ArticleDOI
MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases
TL;DR: The overlapping miRNA signature across the diseases is identified, including miR-128,MiR-140-5p,miR-206, mi R-326, and MiR-155, associated with multiple etiological cellular mechanisms.
References
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Journal ArticleDOI
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk,Matthew G. Vander Heiden,Marian H. Harris,Arvind Ramanathan,Robert E. Gerszten,Robert E. Gerszten,Ru Wei,Mark D. Fleming,Stuart L. Schreiber,Stuart L. Schreiber,Lewis C. Cantley,Lewis C. Cantley +11 more
TL;DR: It is demonstrated that M2 expression is necessary for aerobic glycolysis and that this metabolic phenotype provides a selective growth advantage for tumour cells in vivo.
Journal ArticleDOI
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective.
Rudolph E. Tanzi,Lars Bertram +1 more
TL;DR: The amyloid hypothesis based on both known and putative Alzheimer's disease genes is assessed, with positive results for beta-amyloid inaques andaques is confirmed in animals and humans.
Journal ArticleDOI
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Inki Kim,Wenjie Xu,John C. Reed +2 more
TL;DR: The accumulation of unfolded proteins in the endoplasmic reticulum represents a cellular stress induced by multiple stimuli and pathological conditions, which triggers an evolutionarily conserved series of signal-transduction events, which constitutes the unfolded protein response.
Journal ArticleDOI
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
Yasushi Okazaki,Masaaki Furuno,Takeya Kasukawa,Jun Adachi,Hidemasa Bono,S. Kondo,Itoshi Nikaido,Naoki Osato,Rintaro Saito,Harukazu Suzuki,Itaru Yamanaka,H. Kiyosawa,Ken Yagi,Yasuhiro Tomaru,Yuki Hasegawa,A. Nogami,Christian Schönbach,Takashi Gojobori,Richard M. Baldarelli,David P. Hill,Carol J. Bult,David A. Hume,John Quackenbush,Lynn M. Schriml,Alexander Kanapin,Hideo Matsuda,Serge Batalov,Kirk W. Beisel,Judith A. Blake,Dirck W. Bradt,Vladimir Brusic,Cyrus Chothia,Lori E. Corbani,S. Cousins,Emiliano Dalla,Tommaso A. Dragani,Colin F. Fletcher,Colin F. Fletcher,Alistair R. R. Forrest,K. S. Frazer,Terry Gaasterland,Manuela Gariboldi,Carmela Gissi,Adam Godzik,Julian Gough,Sean M. Grimmond,Stefano Gustincich,Nobutaka Hirokawa,Ian J. Jackson,Erich D. Jarvis,Akio Kanai,Hideya Kawaji,Hideya Kawaji,Yuka Imamura Kawasawa,Rafal M. Kedzierski,Benjamin L. King,Akihiko Konagaya,Igor V. Kurochkin,Yong-Hwan Lee,Boris Lenhard,Paul A. Lyons,Donna Maglott,Lois J. Maltais,Luigi Marchionni,Louise M. McKenzie,Harukata Miki,Takeshi Nagashima,Koji Numata,Toshihisa Okido,William J. Pavan,Geo Pertea,Graziano Pesole,Nikolai Petrovsky,Ramesh S. Pillai,Joan Pontius,D. Qi,Sridhar Ramachandran,Timothy Ravasi,Jonathan C. Reed,Deborah J Reed,Jeffrey G. Reid,Brian Z. Ring,M. Ringwald,Albin Sandelin,Claudio Schneider,Colin A. Semple,Mitsutoshi Setou,K. Shimada,Razvan Sultana,Yoichi Takenaka,Martin S. Taylor,Rohan D. Teasdale,Masaru Tomita,Roberto Verardo,Lukas Wagner,Claes Wahlestedt,Y. Wang,Yoshiki Watanabe,Christine A. Wells,Laurens G. Wilming,Anthony Wynshaw-Boris,Masashi Yanagisawa,Ivana V. Yang,L. Yang,Zheng Yuan,Mihaela Zavolan,Yunhui Zhu,Anne M. Zimmer,Piero Carninci,N. Hayatsu,Tomoko Hirozane-Kishikawa,Hideaki Konno,M. Nakamura,Naoko Sakazume,K. Sato,Toshiyuki Shiraki,Kazunori Waki,Jun Kawai,Katsunori Aizawa,Takahiro Arakawa,S. Fukuda,A. Hara,W. Hashizume,K. Imotani,Y. Ishii,Masayoshi Itoh,Ikuko Kagawa,A. Miyazaki,K. Sakai,D. Sasaki,K. Shibata,Akira Shinagawa,Ayako Yasunishi,Masayasu Yoshino,Robert H. Waterston,Eric S. Lander,Jane Rogers,Ewan Birney,Yoshihide Hayashizaki +138 more
TL;DR: The present work, completely supported by physical clones, provides the most comprehensive survey of a mammalian transcriptome so far, and is a valuable resource for functional genomics.
Journal ArticleDOI
Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease
D. Allan Butterfield,H. Fai Poon,Daret K. St. Clair,Jeffery N. Keller,William M. Pierce,Jon B. Klein,William R. Markesbery +6 more
TL;DR: It is concluded that protein oxidation plays a significant role in the development of AD from MCI and that the oxidative inactivation of ENO1, GLUL, PKM2 and PIN1 is involved in the progression of AD in MCI relevant to oxidative stress.