Journal ArticleDOI
Loganin improves learning and memory impairments induced by scopolamine in mice.
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TLDR
Loganin may have anti-amnesic activity that may hold significant therapeutic value in alleviating certain memory impairments observed in Alzheimer's disease.About:
This article is published in European Journal of Pharmacology.The article was published on 2009-10-01. It has received 123 citations till now. The article focuses on the topics: Loganin & Morris water navigation task.read more
Citations
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Journal ArticleDOI
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.
Sangjune Kim,Seung-Hwan Kwon,Tae In Kam,Nikhil Panicker,Senthilkumar S. Karuppagounder,Saebom Lee,Jun Hee Lee,Wonjoong Richard Kim,Minjee Kook,Catherine A. Foss,Chentian Shen,Hojae Lee,Subhash Kulkarni,Pankaj J. Pasricha,Gabsang Lee,Martin G. Pomper,Valina L. Dawson,Ted M. Dawson,Han Seok Ko +18 more
TL;DR: This study supports the Braak hypothesis in the etiology of idiopathic Parkinson's disease by assessing α- synucleinopathy in the brain in a novel gut-to-brain α-syn transmission mouse model, where pathologicalα-syn preformed fibrils were injected into the duodenal and pyloric muscularis layer.
Journal ArticleDOI
Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice
Seung-Hwan Kwon,Ha-Kyung Lee,Ji-Ah Kim,Sa-Ik Hong,Hyoung-Chun Kim,Tae-Hyung Jo,Young-In Park,Chong-Kil Lee,Yong-Bin Kim,Seok-Yong Lee,Choon-Gon Jang +10 more
TL;DR: Results indicate that chlorogenic acid may exert anti-amnesic activity via inhibition of acetylcholinesterase and malondialdehyde in the hippocampus and frontal cortex in a dose-dependent manner.
Journal ArticleDOI
Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells.
Seung-Hwan Kwon,Ji-Ah Kim,Sa-Ik Hong,Yang-Hee Jung,Hyoung-Chun Kim,Seok-Yong Lee,Choon-Gon Jang +6 more
TL;DR: Loganin's neuroprotective properties indicate that this compound may be a potential therapeutic agent for the treatment of neurodegenerative diseases.
Journal ArticleDOI
Resveratrol, pterostilbene, and dementia.
Klaus W. Lange,Shiming Li +1 more
TL;DR: The findings of available intervention trials of resveratrol in individuals with mild cognitive impairment or AD do not provide evidence of neuroprotective or therapeutic effects, and future clinical trials should be conducted with long‐term exposure to preparations of res veratrol and pterostilbene with high bioavailability.
Book ChapterDOI
Effect of Chinese Herbal Medicine on Alzheimer's Disease.
TL;DR: In this article, the authors discuss available scientific evidence for Chinese herbal medicine (CHM) plants and formulae that have been used both traditionally for AD, and those that were used traditionally but not specifically for AD symptoms, and encompasses chemical, pharmacological and clinical studies.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
A new and rapid colorimetric determination of acetylcholinesterase activity.
TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.
Journal ArticleDOI
Developments of a water-maze procedure for studying spatial learning in the rat
TL;DR: Developments of an open-field water-maze procedure in which rats learn to escape from opaque water onto a hidden platform are described, suggesting that they may lend themselves to a variety of behavioural investigations, including pharmacological work and studies of cerebral function.
Journal ArticleDOI
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Raymond T. Bartus,Raymond T. Bartus,Reginald L. Dean,Bernard Beer,Bernard Beer,Arnold S. Lippa,Arnold S. Lippa +6 more
TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TL;DR: By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.
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