Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis.
Yeon Sik Hong,Su Jin Moon,Young Bin Joo,Chan Hong Jeon,Mi La Cho,Ji Hyeon Ju,Hye Jwa Oh,Yu-Jung Heo,Sung Hwan Park,Ho-Youn Kim,Jun-Ki Min +10 more
TLDR
IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA, and the levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naïve RA.Abstract:
The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 ± 464.0 pg/mL) than in healthy controls (96.0 ± 236.9 pg/mL, P = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (P = 0.042). A significant relationship was found between the levels of IL-33 and IL-1β (r = 0.311, P = 0.005), and IL-33 and IL-6 (r = 0.264, P = 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naive RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA.read more
Citations
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Single nucleotide polymorphisms of the interleukin-33 (IL-33) gene are associated with ankylosing spondylitis in Chinese individuals: a case-control pilot study.
Dazhi Fan,Ning Ding,Ting Yang,Shanshan Wu,Si Liu,Li Liu,Yanting Hu,Zhenhua Duan,Guo Xia,Shengqian Xu,Jianhua Xu,Changhai Ding,Faming Pan +12 more
TL;DR: The results suggest that SNPs and the TTCG haplotype of the IL-33 gene are associated with the development of AS in a Chinese Han population.
Journal ArticleDOI
Serum levels of IL-33 and its receptor ST2 are elevated in patients with ankylosing spondylitis.
TL;DR: Serum levels of IL-33 could partially reflect AS disease activity and indicate that IL- 33/ST2 signalling plays an important role in the pathogenesis of AS.
Journal ArticleDOI
miR-487b mitigates chronic heart failure through inhibition of the IL-33/ST2 signaling pathway
TL;DR: Estimation of the effects of microRNA-587b in a rat model of chronic heart failure found that it reduces apoptosis, inflammatory responses, and fibrosis in CHF by suppressing IL-33 through inhibition the IL- 33/ST2 signaling pathway.
Journal ArticleDOI
Interleukin-33 Synergistically Enhances Immune Complex-Induced Tumor Necrosis Factor Alpha and Interleukin-8 Production in Cultured Human Synovium-Derived Mast Cells
Jun-ichi Kashiwakura,Masahiko Yanagisawa,Hyunho Lee,Yuki Okamura,Tomomi Sasaki-Sakamoto,Shu Saito,Yasuaki Tokuhashi,Chisei Ra,Yoshimichi Okayama +8 more
TL;DR: Interleukin (IL)-33 synergistically enhanced IC-induced IL-8 and TNF-α production in SyMCs, and ICs and IL-33 may exacerbate inflammation associated with RA by abundantly producing T NF-α andIL-8 fromSyMCs.
Journal Article
Serum levels of soluble ST2 and interleukin-33 in patients with dermatomyositis and polymyositis.
TL;DR: Sera sST2 levels were significantly higher in DM and PM patients and correlated with CRP, CK, LDH and VAS, and data support that s ST2 may play a role inDM and PM.
References
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The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.
Frank C. Arnett,Steven M. Edworthy,Daniel A. Bloch,Dennis J. McShane,James F. Fries,Norman S. Cooper,L. A. Healey,Stephen R. Kaplan,Matthew H. Liang,Harvinder S. Luthra,Thomas A. Medsger,Donald M. Mitchell,David H. Neustadt,Robert S. Pinals,Jane G. Schaller,John T. Sharp,Ronald L. Wilder,Gene G. Hunder +17 more
TL;DR: The revised criteria for the classification of rheumatoid arthritis (RA) were formulated from a computerized analysis of 262 contemporary, consecutively studied patients with RA and 262 control subjects with rheumatic diseases other than RA (non-RA).
Journal Article
Revised criteria for the classification of rheumatoid arthritis.
TL;DR: The Bulletin on the Rheumatic Diseases has published all of the classification criteria for the rheumatic diseases to date, and these new revised classified criteria for rheumatoid arthritis are very important as they should provide understanding of the possibly changing face of rheumatism.
Journal ArticleDOI
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
Jochen Schmitz,Alexander Owyang,Elizabeth R. Oldham,Yaoli Song,Erin Murphy,Terril K. McClanahan,Gerard Zurawski,Mehrdad M. Moshrefi,Jinzhong Qin,Xiaoxia Li,Daniel M. Gorman,J. Fernando Bazan,Robert A. Kastelein +12 more
TL;DR: A member of theIL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T( H)2 cells is reported.
Journal ArticleDOI
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
TL;DR: The current knowledge regarding the role of proinflammatory cytokines in the pathophysiology of OA is discussed and the potential of anticytokine therapy in the treatment of this disease is addressed.
Journal ArticleDOI
Disease-associated functions of IL-33: the new kid in the IL-1 family.
TL;DR: IL-33 is host-protective against helminth infection and reduces atherosclerosis by promoting TH2-type immune responses but can also promote the pathogenesis of asthma by expanding TH2 cells and mediate joint inflammation, atopic dermatitis and anaphylaxis by mast cell activation.