Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis.
Yeon Sik Hong,Su Jin Moon,Young Bin Joo,Chan Hong Jeon,Mi La Cho,Ji Hyeon Ju,Hye Jwa Oh,Yu-Jung Heo,Sung Hwan Park,Ho-Youn Kim,Jun-Ki Min +10 more
TLDR
IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA, and the levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naïve RA.Abstract:
The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 ± 464.0 pg/mL) than in healthy controls (96.0 ± 236.9 pg/mL, P = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (P = 0.042). A significant relationship was found between the levels of IL-33 and IL-1β (r = 0.311, P = 0.005), and IL-33 and IL-6 (r = 0.264, P = 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naive RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA.read more
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Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
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References
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Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages
Tatsukuni Ohno,Keisuke Oboki,Naoki Kajiwara,Eiichi Morii,Katsuyuki Aozasa,Richard A. Flavell,Ko Okumura,Hirohisa Saito,Susumu Nakae +8 more
TL;DR: It is shown that mouse peritoneal macrophages, but not splenic dendritic cells, produced IL-33 upon stimulation with LPS, and caspase-1-deficient, caspasase-8-treated, and calpain inhibitor-treated macrophage production was found even in caspases, suggesting that casp enzyme-1-, caspasing-8, andCalpain-independent IL- 33 production by macrophaging and/or mast
Journal ArticleDOI
Tissue Distribution and Subcellular Localization of a Variant Form of the Human ST2 Gene Product, ST2V
Kenji Tago,Takahiro Noda,Morisada Hayakawa,Hiroyuki Iwahana,Ken Yanagisawa,Takashi Yashiro,Shin-ichi Tominaga +6 more
TL;DR: RT-PCR procedure and confocal laser microscopic analysis indicate that ST2V protein localizes on the plasma membrane, suggesting its possible role in modification of the ST2L-signaling pathways.
Journal ArticleDOI
IL-33 Exacerbates Autoantibody-Induced Arthritis
Damo Xu,Hui-Rong Jiang,Yubin Li,Peter Natesan Pushparaj,Mariola Kurowska-Stolarska,Bernard P. Leung,Rong Mu,Hwee Kee Tay,Andrew N. J. McKenzie,Iain B. McInnes,Alirio J. Melendez,Foo Y. Liew +11 more
TL;DR: It is demonstrated that IL-33 can enhance autoantibody-mediated articular inflammation via promoting mast cell degranulation and proinflammatory cytokine production in inflammatory arthritis.
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Rheumatoid arthritis synovium contains plasmacytoid dendritic cells
Lois L. Cavanagh,Amanda Boyce,Louise Smith,Jagadish Padmanabha,Luis Filgueira,Peter Pietschmann,Ranjeny Thomas +6 more
TL;DR: In this paper, an enrichment of antigen-presenting HLA-DR+ nuclear RelB+ dendritic cells (DCs) in rheumatoid arthritis (RA) synovium was described.
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Elevated Serum Interleukin 33 Is Associated with Autoantibody Production in Patients with Rheumatoid Arthritis
TL;DR: No correlation was found between IL-33 concentration and acute-phase inflammation reactant or the score of the Disease Activity Index, suggesting a complex or indirect character of the link between IL -33 and the inflammation in RA.