Modular organization of SARS coronavirus nucleocapsid protein
Chung-ke Chang,Shih Che Sue,Tsan Hung Yu,Chiu Min Hsieh,Cheng Kun Tsai,Cheng Kun Tsai,Yen Chieh Chiang,Shin Jye Lee,Hsin Hao Hsiao,Wen-Jin Wu,Wei Lun Chang,Chun-Hung Lin,Tai Huang Huang,Tai Huang Huang +13 more
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TLDR
This study provides information on the domain structure partition of SARS-CoV N protein and insights into the differing roles of structured and disordered regions in coronavirus nucleocapsid proteins.Citations
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Coronaviruses: An Overview of Their Replication and Pathogenesis
Anthony R. Fehr,Stanley Perlman +1 more
TL;DR: A brief introduction to coronaviruses is provided discussing their replication and pathogenicity, and current prevention and treatment strategies, and the outbreaks of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the recently identified Middle Eastern Respiratories Syndrome Cor onavirus
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Emerging coronaviruses: Genome structure, replication, and pathogenesis.
Yu Chen,Qianyun Liu,Deyin Guo +2 more
TL;DR: This review will help understand the biology and potential risk of CoVs that exist in richness in wildlife such as bats and describe diseases caused by different CoVs in humans and animals.
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Coronavirus Disease 2019–COVID-19
Kuldeep Dhama,Khan Sharun,Ruchi Tiwari,Shubhankar Sircar,Sudipta Bhat,Yashpal Singh Malik,Karam Pal Singh,Wanpen Chaicumpa,D. Katterine Bonilla-Aldana,Alfonso J. Rodriguez-Morales +9 more
TL;DR: Analysis of epidemiological, diagnostic, clinical, and therapeutic aspects, including perspectives of vaccines and preventive measures that have already been globally recommended to counter this pandemic virus, suggest that this novel virus has been transferred from an animal source, such as bats.
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The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China.
Yongshi Yang,Fujun Peng,Runsheng Wang,Kai Guan,Taijiao Jiang,Guogang Xu,Jinlyu Sun,Christopher Chang,Christopher Chang +8 more
TL;DR: It is clear that finding an effective antiviral and developing a vaccine are still significant challenges, as the SARS-CoV-2 virus has led to significant sociological, psychological and economic effects globally.
Journal ArticleDOI
The coronavirus nucleocapsid is a multifunctional protein
TL;DR: The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions.
References
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The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.
TL;DR: ClUSTAL X is a new windows interface for the widely-used progressive multiple sequence alignment program CLUSTAL W, providing an integrated system for performing multiple sequence and profile alignments and analysing the results.
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Characterization of a novel coronavirus associated with severe acute respiratory syndrome.
Paul A. Rota,M. Steven Oberste,Stephan S. Monroe,W. Allan Nix,Ray Campagnoli,Joseph P. Icenogle,Silvia Peñaranda,Bettina Bankamp,Kaija Maher,Min hsin Chen,Suxiong Tong,Azaibi Tamin,Luis Lowe,Michael Frace,Joseph L. DeRisi,Qi Chen,David Wang,Dean D. Erdman,Teresa C. T. Peret,Cara C. Burns,Thomas G. Ksiazek,Pierre E. Rollin,Anthony Sanchez,Stephanie L. Liffick,Brian P. Holloway,Josef Limor,Karen A. McCaustland,Mellissa Olsen-Rasmussen,Ron A. M. Fouchier,Stephan Günther,Albert Osterhaus,Christian Drosten,Mark A. Pallansch,Larry J. Anderson,William J. Bellini +34 more
TL;DR: Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closelyrelated to any of the previouslycharacterized coronaviruses.
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1H, 13C and 15N chemical shift referencing in biomolecular NMR
David S. Wishart,Colin G. Bigam,Jian Yao,Frits Abildgaard,H J Dyson,Eric Oldfield,John L. Markley,Brian D. Sykes +7 more
TL;DR: In this paper, a considerable degree of variability exists in the way that 1H, 13C and 15N chemical shifts are reported and referenced for biomolecules and the authors explore some of the reasons for this situation and propose guidelines for future chemical shift referencing and for conversion from many common 1H and 13C chemical shift standards, now used in biomolecular NMR, to those proposed here.
Journal ArticleDOI
The Genome Sequence of the SARS-associated Coronavirus
Marco A. Marra,Steven J.M. Jones,Caroline R. Astell,Robert A. Holt,Angela Brooks-Wilson,Yaron S.N. Butterfield,Jaswinder Khattra,Jennifer Asano,Sarah Barber,Susanna Y. Chan,Alison Cloutier,Shaun M. Coughlin,Doug Freeman,Noreen Girn,Obi L. Griffith,Stephen Leach,Michael Mayo,Helen McDonald,Stephen B. Montgomery,Pawan Pandoh,Anca Petrescu,A. Gordon Robertson,Jacqueline E. Schein,Asim Siddiqui,Duane E. Smailus,Jeff M. Stott,George S. Yang,Francis A. Plummer,Anton Andonov,Harvey Artsob,Nathalie Bastien,Kathy Bernard,Timothy F. Booth,Donnie Bowness,Martin Czub,Michael Drebot,Lisa Fernando,Ramon Flick,Michael Garbutt,Michael Gray,Allen Grolla,Steven M. Jones,Heinz Feldmann,Adrienne Meyers,Amin Kabani,Yan Li,Susan Normand,Ute Ströher,Graham A. Tipples,Shaun Tyler,Robert Vogrig,Diane M. Ward,Brynn Watson,Robert C. Brunham,Mel Krajden,Martin Petric,Danuta M. Skowronski,Chris Upton,Rachel L. Roper +58 more
TL;DR: The genome sequence reveals that the severe acute respiratory syndrome–associated coronavirus known as the Tor2 isolate is only moderately related to other known coronaviruses, andylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronavirs.
Book ChapterDOI
The molecular biology of coronaviruses.
TL;DR: This review summarizes both classical and contemporary discoveries in the study of the molecular biology of these infectious agents, with particular emphasis on the nature and recognition of viral receptors, viral RNA synthesis, and the molecular interactions governing virion assembly.
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