Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders
Kevin Nay,William J. Smiles,Jacqueline Kaiser,Luke M. McAloon,Luke M. McAloon,Kim Loh,Kim Loh,Sandra Galic,Jonathan S. Oakhill,Jonathan S. Oakhill,Andrew L. Gundlach,John W. Scott,John W. Scott,John W. Scott +13 more
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TLDR
In this paper, the authors summarize the most relevant current knowledge of the impact of exercise on mood disorders and neurodegenerative diseases, and highlight the established and potential underlying mechanisms involved in exercise-brain communication and their benefits for physiology and brain function.Abstract:
As life expectancy has increased, particularly in developed countries, due to medical advances and increased prosperity, age-related neurological diseases and mental health disorders have become more prevalent health issues, reducing the well-being and quality of life of sufferers and their families. In recent decades, due to reduced work-related levels of physical activity, and key research insights, prescribing adequate exercise has become an innovative strategy to prevent or delay the onset of these pathologies and has been demonstrated to have therapeutic benefits when used as a sole or combination treatment. Recent evidence suggests that the beneficial effects of exercise on the brain are related to several underlying mechanisms related to muscle-brain, liver-brain and gut-brain crosstalk. Therefore, this review aims to summarize the most relevant current knowledge of the impact of exercise on mood disorders and neurodegenerative diseases, and to highlight the established and potential underlying mechanisms involved in exercise-brain communication and their benefits for physiology and brain function.read more
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Convergent pathways of the gut microbiota–brain axis and neurodegenerative disorders
TL;DR: Based on the current literature, the potential for different microbiota-based therapeutic strategies to prevent, to modify, or to halt the progress of neurodegeneration is examined.
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The Role of TDP-43 in Neurodegenerative Disease
Yangyou Liao,Jing Ma,Jie-Zhi Dou +2 more
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Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?
TL;DR: In this paper , several strategies are proposed to improve brain ageing by attenuating age-related neurodegenerative disease mechanisms, but also maintaining cognitive function in a variety of pre-clinical experimental murine models.
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OUP accepted manuscript
TL;DR: In this paper , the authors provide an overview of the gut microbiota axis pathways and discuss the potential for different microbiota-based therapeutic strategies to prevent, to modify, or to halt the progress of neurodegeneration.
Journal ArticleDOI
Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease.
Irina Belaya,Nina Kucháriková,Veronika Gorova,Kai Kysenius,Dominic J. Hare,Dominic J. Hare,Peter J. Crouch,Tarja Malm,Mustafa Atalay,Anthony R. White,Jeffrey R. Liddell,Katja M. Kanninen +11 more
TL;DR: In this paper, the effect of regular physical exercise on modulation of iron homeostasis in the brain and periphery of the 5xFAD mouse model of Alzheimer's disease was explored, and it was shown that long-term voluntary running induced redistribution of iron resulted in altered iron metabolism and trafficking in brain and increased iron content in skeletal muscle.
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