Journal ArticleDOI
Natural history of hepatitis C
TLDR
The authors in this paper found that approximately 85% of persons with acute hepatitis C develop chronic hepatitis as determined by persistently abnormal serum enzymes and/or viremia (hepatitis C virus [HCV] RNA).About:
This article is published in Hepatology.The article was published on 1997-12-01. It has received 506 citations till now. The article focuses on the topics: Hepatitis & Hepatitis C.read more
Citations
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Journal ArticleDOI
Natural history of hepatitis C
TL;DR: In this paper, the authors provided varying estimates of the risk of progression in chronic hepatitis C. The combined population data indicated that the disease progresses slowly over approximately 30 years, on average.
Journal ArticleDOI
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
Kui Li,Eileen Foy,Josephine C. Ferreon,Mitsuyasu Nakamura,Allan Chris M. Ferreon,Masanori Ikeda,Stuart C. Ray,Michael Gale,Stanley M. Lemon +8 more
TL;DR: It is shown that the NS3/4A serine protease of hepatitis C virus (HCV) causes specific proteolysis of Toll-IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF or TICAM-1), an adaptor protein linking TLR3 to kinases responsible for activating IFN regulatory factor 3 (IRF-3) and NF-kappaB, transcription factors controlling a multiplicity of antiviral defenses.
Journal ArticleDOI
The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013
Jeffrey D. Stanaway,Abraham D. Flaxman,Mohsen Naghavi,Christina Fitzmaurice,Christina Fitzmaurice,Theo Vos,Ibrahim Abubakar,Laith J. Abu-Raddad,Reza Assadi,Neeraj Bhala,Neeraj Bhala,Benjamin C Cowie,Mohammad H. Forouzanfour,Justina Groeger,Khayriyyah Mohd Hanafiah,Khayriyyah Mohd Hanafiah,Kathryn H. Jacobsen,Spencer L. James,Jennifer H MacLachlan,Reza Malekzadeh,Natasha K. Martin,Natasha K. Martin,Ali A. Mokdad,Ali H. Mokdad,Christopher J L Murray,Dietrich Plass,Saleem M Rana,David B. Rein,Jan Hendrik Richardus,Juan Sanabria,Juan Sanabria,Mete Saylan,Saeid Shahraz,Samuel So,Vasiliy Victorovich Vlassov,Elisabete Weiderpass,Steven T. Wiersma,Mustafa Z. Younis,Chuanhua Yu,Maysaa El Sayed Zaki,Graham S Cooke +40 more
TL;DR: The enormous health loss attributable to viral hepatitis, and the availability of effective vaccines and treatments, suggests an important opportunity to improve public health.
Journal ArticleDOI
The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies.
Patrizia Farci,Atsushi Shimoda,Alessandra Coiana,Giacomo Diaz,Giovanna Peddis,Jacqueline C. Melpolder,Antonello Strazzera,David Y. Chien,Santiago J. Munoz,Angelo Balestrieri,Robert H. Purcell,Harvey J. Alter +11 more
TL;DR: Sequences within the HCV E1 and E2 envelope genes were analyzed during the acute phase of hepatitis C in 12 patients with different clinical outcomes to indicate that the evolutionary dynamics of theHCV quasispecies during the emergency phase predict whether the infection will resolve or become chronic.
Journal ArticleDOI
Estimation of stage-specific fibrosis progression rates in chronic hepatitis C virus infection: A meta-analysis and meta-regression†
TL;DR: A large systematic review of published prognostic studies provides increased precision in estimating fibrosis progression in chronic HCV infection and supports nonlinear disease progression.
References
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Journal ArticleDOI
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
TL;DR: A random-primed complementary DNA library was constructed from plasma containing the uncharacterized non-A, non-B hepatitis agent and screened with serum from a patient diagnosed with NANBH, showing consistent with the agent being similar to the togaviridae or flaviviridae.
Journal ArticleDOI
Histological grading and staging of chronic hepatitis.
Kamal G. Ishak,Amelia Baptista,Leonardo Bianchi,Francesco Callea,Jan De Groote,Fred Gudat,Helmut Denk,Valeer Desmet,Gerhard Korb,R. N. M. Macsween,M. James Phillips,Bernard G. Portmann,H. Poulsen,Peter J. Scheuer,Martin Schmid,Heribert Thaler +15 more
TL;DR: This research presents a meta-analysis of Anatomia e Istologia Patologica, a large quantity of which has never before been published in a peer-reviewed journal, which aims to provide real-time information about the immune system’s response to disease.
Journal ArticleDOI
An algorithm for the grading of activity in chronic hepatitis C
Pierre Bedossa,Thierry Poynard +1 more
TL;DR: A simple algorithm that generates a single activity score based on basic pathological features in chronic hepatitis C is proposed and tested, showing its accuracy is as high as that obtained using a statistical approach.
Journal ArticleDOI
Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
Robert G. Knodell,Kamal G. Ishak,William C. Black,Thomas S. Chen,Robert M. Craig,Neil Kaplowitz,T Kiernan,Jerome Wollman +7 more
TL;DR: A Histology Activity Index has been developed which generates a numerical score for liver biopsy specimens obtained from patients with asymptomatic chronic active hepatitis that provides definitive endpoints for statistical analysis of serial changes in liver histology and offers an alternative to the use of conventional pathological descriptions.
Journal ArticleDOI
Natural history of liver fibrosis progression in patients with chronic hepatitis C
TL;DR: The host factors of ageing, alcohol consumption, and male sex have a stronger association with fibrosis progression than virological factors in HCV infection.