Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
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TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
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Journal ArticleDOI
In Situ Colorimetric Quantification of Silver Cations in the Presence of Silver Nanoparticles
R.A. González-Fuenzalida,Yolanda Moliner-Martínez,María González-Béjar,Carmen Molins-Legua,Jorge Verdú-Andrés,Julia Pérez-Prieto,Pilar Campíns-Falcó +6 more
TL;DR: Silver ions (Ag(+)) can be quantified in situ in the presence of AgNPs by using a colorimetric sensing probe (3,3',5,5'-tetramethylbenzidine) that also enables detection of the Ag(+) adsorbed on the AgNP surface.
Journal ArticleDOI
Electroactive biomimetic collagen-silver nanowire composite scaffolds
Abeni Wickham,Mikhail Vagin,Hazem Khalaf,Sergio Bertazzo,Peter Hodder,Staffan Dånmark,Torbjörn Bengtsson,Jordi Altimiras,Daniel Aili +8 more
TL;DR: The developed collagen/AgNW composites represent a highly attractive bioelectrode and scaffold material for a wide range of biomedical applications.
Journal ArticleDOI
Antimicrobial Activity of Silver-Treated Bacteria Against Other Multi-Drug Resistant Pathogens in Their Environment
TL;DR: Both silver-killed bacteria and supernatant showed prolonged antimicrobial activity against the tested strains that extended to 40 days and promoted its use as a powerful disinfectant for polluted water and as an effective antibacterial which can be included in wound and burn dressings to overcome the problem of wound contamination.
Journal ArticleDOI
Size controlled biogenic silver nanoparticles as antibacterial agent against isolates from HIV infected patients.
K.S. Uma Suganya,Kasivelu Govindaraju,V. Ganesh Kumar,T. Stalin Dhas,V. Karthick,Ganesan Singaravelu,M. Elanchezhiyan +6 more
TL;DR: The size and shape controlled synthesis of AgNPs using the aqueous extract of blue green alga, Spirulina platensis were reported, which were stable, well defined and monodispersed (spherical) with an average size of 6 nm.
Journal ArticleDOI
Preparation and controlled coating of hydroxyl-modified silver nanoparticles on silk fibers through intermolecular interaction-induced self-assembly
Sijun Xu,Sijun Xu,Siyu Chen,Feng Zhang,Chenlu Jiao,Jianchao Song,Yuyue Chen,Hong Lin,Yasuo Gotoh,Hideaki Morikawa +9 more
TL;DR: In this paper, a self-assembly of hyperbranched poly(amine-ester)s modified silver nanoparticles (HBPAE/AgNPs) on modified silk fibers (HBPAA/SFs) is described.
References
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Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
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