Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
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TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
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β-Chitin nanofiber hydrogel as a scaffold to in situ fabricate monodispersed ultra-small silver nanoparticles
TL;DR: In this paper, β-chitin nanofibers (β-ChNFs) were efficiently prepared from squid pens by a combination of ball milling and ultrasonic techniques.
Journal ArticleDOI
In situ generation of silver nanoparticles and nanocomposite films based on electrodeposition of carboxylated chitosan
TL;DR: The experimental results indicate that a smooth and homogeneous film is formed on the silver plate after electrodeposition, and the electrodeposited film can be detached from thesilver plate as an independent film.
Journal ArticleDOI
Impact of labile metal nanoparticles on cellular homeostasis. Current developments in imaging, synthesis and applications.
Mireille Chevallet,Giulia Veronesi,Alexandra Fuchs,Elisabeth Mintz,Isabelle Michaud-Soret,Aurélien Deniaud,Aurélien Deniaud +6 more
TL;DR: This review describes the current knowledge about the toxicity of labile metal nanoparticles both at the organism and cellular levels, and describes the pathways that are triggered to maintain cellular homeostasis and promises new insights into nanoparticle fate and toxicity.
Journal ArticleDOI
Effects of low dose silver nanoparticle treatment on the structure and community composition of bacterial freshwater biofilms.
Alexandra Grün,Constantin B. App,Andreas Breidenbach,Jutta Meier,George Metreveli,Gabriele E. Schaumann,Werner Manz +6 more
TL;DR: Changes in community composition were related with the displacement of putatively AgNP-sensitive bacterial taxa Actinob bacteria, Chloroflexi, and Cyanobacteria by taxa known for their enhanced adaptability towards metal stress, such as Acidobacteria, Sphingomonadales, and Comamonadaceae.
Journal ArticleDOI
Trophic transfer of citrate, PVP coated silver nanomaterials, and silver ions in a paddy microcosm.
Hyung-Geun Park,Jung In Kim,Kwang-Hyeon Chang,Byoungcheun Lee,Ig-Chun Eom,Pilje Kim,Dong-Ha Nam,Min-Kyeong Yeo +7 more
TL;DR: Estimation of tropic transfer of citrate-coated silver nanoparticles, polyvinylpyrrolidone -coated AgNP, and silver ions under replicated paddy microcosm systems suggest that AgNPs have the potential to impact on ecological receptors and food chains.
References
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Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
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