Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
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TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
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Au-Ag core-shell nanoparticles for simultaneous bacterial imaging and synergistic antibacterial activity
TL;DR: Au@Ag NPs showed strong antibacterial activity (minimum inhibition concentration as low as 7.5pM against Staphylococcus aureus) and negligible toxicity to human dermal fibroblasts, and their bactericidal activity was further enhanced under NIR irradiation due to strong two-photon photothermal effects.
Journal ArticleDOI
Phytotoxicity, uptake and transformation of nano-CeO2 in sand cultured romaine lettuce
Peng Zhang,Yuhui Ma,Shutong Liu,Guohua Wang,Junzhe Zhang,Xiao He,Jing Zhang,Yukui Rui,Zhiyong Zhang +8 more
TL;DR: X ray absorption near edge spectroscopy results indicate that release of Ce3+ played a critical role in the toxicity nCeO2, indicating that releaseof Ce3+, which can be converted to toxic nitrite in humans thereby posed risk to human health.
Journal ArticleDOI
Effects of Ag and Ag2S nanoparticles on denitrification in sediments.
TL;DR: It is demonstrated that the inhibitory effect of Ag-containing NPs on denitrification in sediments depends on their morphology and type, implying that the stability and toxicity of Ag/S NPs should be considered with caution.
Journal ArticleDOI
Photoreduction and Stabilization Capability of Molecular Weight Fractionated Natural Organic Matter in Transformation of Silver Ion to Metallic Nanoparticle
TL;DR: Compared with low MW fractions, the high MW Mf-NOMs exhibit drastically higher capability in stabilizing the photosynthesized AgNPs against Ca(2+)-induced aggregation and are important for a better understanding of the differential roles of Mf -NOM in the transformation and transport of Ag(+) and engineered AgNps in DOM-rich surface water.
Journal ArticleDOI
Silver(I) complex formation with cysteine, penicillamine, and glutathione
TL;DR: A redetermination of the crystal structure of Ag(HPen)·H2O (2) confirmed the proposed digonal AgS2 coordination environment to bridging thiolate sulfur atoms in polymeric intertwining chains forming a double helix.
References
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Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
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