Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
Reads0
Chats0
TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
More filters
Journal ArticleDOI
The effects of metallic engineered nanoparticles upon plant systems: An analytic examination of scientific evidence
Thabet Tolaymat,Ash Genaidy,Wael H.M. Abdelraheem,Dionysios D. Dionysiou,Christian P. Andersen +4 more
TL;DR: Analysis of evidence demonstrated that metallic ENPs have both stimulatory and inhibitory effects mostly in well-controlled environments and soilless media, and precautions should be taken to avoid higher concentrations not only for plant systems, but also, other constituents in the SEE.
Journal ArticleDOI
Silver doped titanium dioxide nanoparticles as antimicrobial additives to dental polymers
TL;DR: Ag-TiO2 filled resin shows promising antimicrobial properties, which could potentially be used clinically, and was able to produce a bactericidal effect when in contact with S. mutans under visible light conditions.
Journal ArticleDOI
Discriminating the states of matter in metallic nanoparticle transformations: what are we missing?
TL;DR: Because the capability of the coupled A4F system is extended to reliably detect, characterize, and quantify metallic populations in the sub-5 nm regime, the opportunity exists to survey the formation and transformation products of nanomaterials in more relevant biological and environmental systems.
Journal ArticleDOI
Surface matters: enhanced bactericidal property of core-shell Ag-Fe2O3 nanostructures to their heteromer counterparts from one-pot synthesis.
Yingjie Chen,Nan Gao,Jiang Jiang +2 more
TL;DR: The core-shell nanoparticles show superior antibacterial properties compared to their heteromer counterparts and plain Ag nanoparticles, and the mechanism for the increased efficiency is proposed to be due to the enhanced Ag ion release from the iron oxide shell-protected pristine Ag surface.
Journal ArticleDOI
Highly bactericidal Ag nanoparticle films obtained by cluster beam deposition
Emanuele Cavaliere,Sebastiano De Cesari,Giulia Landini,Eleonora Riccobono,Lucia Pallecchi,Gian Maria Rossolini,Gian Maria Rossolini,Luca Gavioli +7 more
TL;DR: The authors here describe the technique of cluster beam deposition for spraying silver on surfaces used in health care sectors, to obtain antimicrobial Ag nanoparticle films deposited directly on surfaces, which may open a new avenue for future anti-bacterial coatings.
References
More filters
Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
Related Papers (5)
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria
Ivan Sondi,Branka Salopek-Sondi +1 more