Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
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TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
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Engineering polydopamine-glued sandwich-like nanocomposites with antifouling and antibacterial properties for the development of advanced mixed matrix membranes
Xiaoyan Guo,Chunyu Li,Shougang Fan,Zhan Gao,Lin Tong,Huiyu Gao,Qixing Zhou,Huaiqi Shao,Yuan Liao,Qilin Li,Wanli Hu +10 more
TL;DR: In this paper, the authors have developed a facile method for engineering the nanomaterials with excellent capabilities though PDA coating and electroless silver plating, which can be uniformly distributed in the polyvinylidene fluoride (PVDF) matrices of the membranes.
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Use of silver-based additives for the development of antibacterial functionality in Laser Sintered polyamide 12 parts.
TL;DR: This work presents a new approach to introducing antibacterial properties into AM, using Laser Sintering, by combining antimicrobial and base polymer powders prior to processing, and shows that the mechanical properties of the resultant composite parts are similar to standard polymer parts and reveal the mode of the antibacterial activity.
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Polydopamine for Biomedical Application and Drug Delivery System
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Supraparticles for Sustainability
Susanne Wintzheimer,Susanne Wintzheimer,Jakob Reichstein,Philipp Groppe,Andreas Wolf,Bastian Fett,Huanhuan Zhou,Rosa Pujales-Paradela,Franziska Miller,Stephan Müssig,Sarah Wenderoth,Karl Mandel,Karl Mandel +12 more
TL;DR: In this article, a perspective is provided on why and how the properties of supraparticles, and not simply properties of individual NPs or conventional bulk materials, may grant attractive alternative pathways in these fields.
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Synthesis of water-soluble Cu/PAA composite flowers and their antibacterial activities.
TL;DR: Water-soluble copper/polyacrylic acid composites synthesized by a facile solution-phase reduction route indicated that Cu/PAA flower is selective in its antibacterial action, and displays more effective antibacterial activity against B. subtilis than other three stains, and better bactericidal activity against S. aureus, E. coli and P. aeruginosa.
References
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Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
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