Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
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This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
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Journal ArticleDOI
Citrate-Coated Silver Nanoparticles Growth-Independently Inhibit Aflatoxin Synthesis in Aspergillus parasiticus
Chandrani Mitra,Phani M. Gummadidala,Kamelia Afshinnia,Ruth C. Merrifield,Mohammed Baalousha,Jamie R. Lead,Anindya Chanda +6 more
TL;DR: It is demonstrated that citrate-coated Ag NPs of size 20 nm, when applied at a selected nonlethal dose, can result in a >2 fold inhibition of biosynthesis of the carcinogenic mycotoxin and secondary metabolite, aflatoxin B1 in the filamentous fungus and an important plant pathogen, Aspergillus parasiticus without inhibiting fungal growth.
Journal ArticleDOI
Coupling of radiofrequency with magnetic nanoparticles treatment as an alternative physical antibacterial strategy against multiple drug resistant bacteria
Akhilesh Kumar Chaurasia,Nanasaheb D. Thorat,Anshula Tandon,Jin-Hahn Kim,Sung Ha Park,Kyeong Kyu Kim +5 more
TL;DR: Results indicate that MCSNP-based physical treatment can be an alternative antibacterial strategy without leading to antibiotic resistance, and can be used for many purposes including environmental and therapeutic applications.
Journal ArticleDOI
Ancient and Novel Forms of Silver in Medicine and Biomedicine
Alireza Ebrahiminezhad,Mohammad Javad Raee,Zahra Manafi,Abdolreza Sotoodeh Jahromi,Younes Ghasemi +4 more
TL;DR: AgNPs would disturb microbial growth through inhibiting the absorption of phosphate, collapsing the proton motive force, forming complexes with DNA, enzyme inactivation, as well as inhibition of glucose oxidation, and inducing bacteria into a viable but non-culturable (VBNC) state and eventually killing them.
Journal ArticleDOI
Fabrication of a Double-Shell Ag/AgCl/G-ZnFe2O4 Nanocube with Enhanced Light Absorption and Superior Photocatalytic Antibacterial Activity.
TL;DR: Efficient synergistic photocatalytic antibacterial activity coupled with magnetic separability and recyclability, shows potential for the practical application of DAGZNs in water cleansing and environmental pollution purifying areas.
Journal ArticleDOI
Using gold nanorods core/silver shell nanostructures as model material to probe biodistribution and toxic effects of silver nanoparticles in mice.
TL;DR: The accumulated silver ions in the kidney not only interacted with the kidney cells membrane but also induced a rapid increase of complement fraction C3 followed by a significant consumption and C3a and C5a production significantly in the serum, which resulted in kidney oxidative damage and eventually led to the morphological changes and filtration function impairment of the glomerulus.
References
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Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
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