Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
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TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
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Journal ArticleDOI
Antimicrobial behavior of biosynthesized silica-silver nanocomposite for water disinfection: a mechanistic perspective.
Thanusu Parandhaman,Thanusu Parandhaman,Anisha Das,Baskaran Ramalingam,Debasis Samanta,Thottapalli Parvathaleswara Sastry,Asit Baran Mandal,Asit Baran Mandal,Sujoy K. Das,Sujoy K. Das +9 more
TL;DR: The biosynthesizedNSAgNC has great potential as disinfectant for water purification while minimizing the toxic effects and the fragmentations of both plasmid and genomic DNA and down regulation of protein expression in NSAgNC treated cells, which leading to the cell death.
Journal ArticleDOI
Antibacterial thin film nanocomposite reverse osmosis membrane by doping silver phosphate loaded graphene oxide quantum dots in polyamide layer
TL;DR: In this article, the authors synthesized a multifunctional nanocomposite of AP loaded with Graphene oxide quantum dots (GOQD) by a facile electrostatically driven method and embedded it into the dense polyamide (PA) layer via interfacial polymerization reaction.
Journal ArticleDOI
Fusarium as a Novel Fungus for the Synthesis of Nanoparticles: Mechanism and Applications.
Mahendra Rai,Shital Bonde,Patrycja Golińska,Joanna Trzcińska-Wencel,Aniket Gade,Kamel A. Abd-Elsalam,Sudhir Shende,Sudhir Shende,Swapnil Gaikwad,Avinash P. Ingle +9 more
TL;DR: In this article, the synthesis of nanoparticles from Fusarium is discussed and its mechanism and applications are discussed. But, the authors do not consider the use of nanoparticle synthesis in medical applications.
Journal ArticleDOI
Plasmonic Ag decorated graphitic carbon nitride sheets with enhanced visible-light response for photocatalytic water disinfection and organic pollutant removal.
TL;DR: Plasmonic Ag doped urea-derived graphitic carbon nitride (g-C3N4) composites were fabricated via in-situ photo-deposition at room temperature as the visible-light photocatalyst and revealed that Ag nanoparticles inhibited the recombination of photo-generated e- and h+ pairs and further reinforced the photocatalytic performance of g-C 3N4.
Journal ArticleDOI
pH-Triggered Controllable Release of Silver–Indole-3 Acetic Acid Complexes from Mesoporous Silica Nanoparticles (IBN-4) for Effectively Killing Malignant Bacteria
TL;DR: The synthesized pH-sensitive IAAH-Ag complex was found to have high antimicrobial efficacy against multidrug resistant clinical isolates both in planktonic and biofilm states and a good in vivo efficacy in treating the bacterial infection of mice.
References
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Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
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