Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
Reads0
Chats0
TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
More filters
Journal ArticleDOI
Antibiofilm Efficacy of Positively Charged Imidazolium-Based Silver Nanoparticles in Enterococcus faecalis Using Quantitative Real-Time PCR
Mohammadreza Nabavizadeh,Abbas Abbaszadegan,Ahmad Gholami,Zahra Kadkhoda,Hosein Mirhadi,Younes Ghasemi,Azam Safari,Bahram Hemmateenejad,Samira Dorostkar,Hashem Sharghi +9 more
TL;DR: In this paper, the antibacterial efficacy of PC Im-based AgNPs at 5.7 × 10-8 mol L-1 in comparison with 2.5% sodium hypochlorite (NaOCl) and 2% chlorhexidine as the two broadly used endodontic irrigation solutions against biofilm E. faecalis using quantitative real-time polymerase chain reaction.
Journal ArticleDOI
Osteogenic and antiseptic nanocoating by in situ chitosan regulated electrochemical deposition for promoting osseointegration.
TL;DR: Electrochemical method was utilized in this research to successfully construct multifunctional composite coatings, such as antibiosis, osteogenesis and angiogenesis, on the surface of Ti, which showed promising capability in inducing BMSCs differentiation to osteoblast, which is proved by the results of fluorescent dye.
Journal ArticleDOI
Antibacterial activity of silver nanoparticles against field and reference strains of Mycobacterium tuberculosis, Mycobacterium bovis and multiple-drug-resistant tuberculosis strains.
TL;DR: The antimycobacterial activity of silver nanoparticles (AgNPs) showed an in vitro chemotherapeutic effect against Mycobacterium spp.
Journal ArticleDOI
Highly-toughened PVA/nanocellulose hydrogels with anti-oxidative and antibacterial properties triggered by lignin-Ag nanoparticles.
Weijun Yang,Fei Xu,Xinyu Ma,Jiaqi Guo,Chengcheng Li,Sudan Shen,Debora Puglia,Jiwei Chen,Pengwu Xu,Jose Maria Kenny,Piming Ma +10 more
TL;DR: In this paper, Ag nanoparticles were firstly reduced on the surface of lignin nanoparticles (LNPAg) by direct reaction of silver nitrate without the use of a catalyst.
Journal Article
Acute toxicity of different sizes of silver nanoparticles intraperitonally injected in balb/c mice using two toxicological methods
TL;DR: The results suggested that the AOT425statPgm method was an efficient tool and a good alternative method for use in future acute toxicity studies.
References
More filters
Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
Related Papers (5)
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria
Ivan Sondi,Branka Salopek-Sondi +1 more