Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
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TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
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Journal ArticleDOI
Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria.
TL;DR: The potential of bacteriophage particles, CRISPR–Cas, and nanotechnology for use in combating human (bacterial) infections is discussed.
Journal ArticleDOI
Biogenic silver nanoparticles inducing Leishmania amazonensis promastigote and amastigote death in vitro.
Jacqueline R. Fanti,Fernanda Tomiotto-Pellissier,Milena Menegazzo Miranda-Sapla,Allan Henrique Depieri Cataneo,Célia Guadalupe Tardeli de Jesus Andrade,Carolina Panis,Jean Henrique da Silva Rodrigues,Pryscilla Fanini Wowk,Diogo Kuczera,Idessania Nazareth Costa,Celso Vataru Nakamura,Gerson Nakazato,Nelson Durán,Wander Rogério Pavanelli,Ivete Conchon-Costa +14 more
TL;DR: It is demonstrated that AgNp-bio had a direct effect against L. amazonensis forms and acted on immunomodulatory ability of infected macrophages, reducing the infection without inducing the synthesis of inflammatory mediators, which continuous stimulation can generate and aggravate leishmaniotic lesions.
Journal ArticleDOI
The antibacterial stability of poly(dopamine) in-situ reduction and chelation nano-Ag based on bacterial cellulose network template
Yajie Xie,Lina Yue,Yudong Zheng,Liang Zhao,Chunyong Liang,Wei He,Zhiwei Liu,Yi Sun,Yingying Yang +8 more
TL;DR: In this paper, the authors used self-polymerization of dopamine to fix the nano-Ag on the bacterial cellulose (BC), and the antibacterial properties of composites were tested in two new methods (antibacterial stability and antibacterial durability).
Journal ArticleDOI
Chiral Nanoparticle as a New Efficient Antimicrobial Nanoagent.
TL;DR: D-type functionalized nanoparticles can bind to MurD ligase with high affinity and inhibit its peptidoglycan synthetic enzyme activity, and finally cause bacterial killing.
Journal ArticleDOI
Regulation of engineered nanomaterials: current challenges, insights and future directions
Racliffe Weng Seng Lai,Katie W.Y. Yeung,Mana M.N. Yung,Aleksandra B. Djurišić,John P. Giesy,John P. Giesy,John P. Giesy,Kenneth M.Y. Leung,Kenneth M.Y. Leung +8 more
TL;DR: To address the fast-growing nanotechnology market with limited resources, four ENMs (nanoparticles of Ag, TiO2, ZnO and Fe2O3) have been prioritized for research and compulsory reporting schemes (registration and labelling) for commercial products containing ENMs should be adopted.
References
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Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
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