Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
Reads0
Chats0
TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
More filters
Journal ArticleDOI
Assessing silver nanoparticles behaviour in artificial seawater by mean of AF4 and spICP-MS.
Diana C. António,Claudia Cascio,Željko Jakšić,Darija Jurašin,Daniel Mark Lyons,António J.A. Nogueira,François Rossi,Luigi Calzolai +7 more
TL;DR: It is shown that the presence of alginate or humic acid differentially affects the kinetic of the agglomeration process of silver nanoparticles in artificial seawater.
Journal ArticleDOI
Selective Killing of Pathogenic Bacteria by Antimicrobial Silver Nanoparticle—Cell Wall Binding Domain Conjugates
Domyoung Kim,Seok Joon Kwon,Xia Wu,Jessica Sauve,Inseon Lee,Jahyun Nam,Jungbae Kim,Jonathan S. Dordick +7 more
TL;DR: It is demonstrated that silver nanoparticles, suitably conjugated to a selective cell wall binding domain (CBD), can efficiently target and selectively kill bacteria.
Journal ArticleDOI
Emerging Concern for Silver Nanoparticle Resistance in Acinetobacter baumannii and Other Bacteria
TL;DR: A. baumannii is a Gram-negative coccobacillus and opportunistic nosocomial bacterial pathogen and was recently listed as the "number one" critical level priority pathogen because of the significant rise of antibiotic resistance in this species as mentioned in this paper.
Journal ArticleDOI
The impact of silver nanoparticles on the composting of municipal solid waste.
Alireza Gitipour,Amro El Badawy,Mahendranath Arambewela,Bradley W. Miller,Kirk G. Scheckel,Michael Elk,Hodon Ryu,Vicente Gomez-Alvarez,Jorge W. Santo Domingo,Stephen W. Thiel,Thabet Tolaymat +10 more
TL;DR: The study evaluates the impact of polyvinylpyrrolidone coated silver nanoparticles (PVP-AgNPs) on the composting of municipal solid waste and suggests that at relatively low concentrations, the organically rich waste management systems' functionality may not be influenced by the presence of AgNPs.
Journal ArticleDOI
Antimicrobial Properties of the Ag, Cu Nanoparticle System.
TL;DR: In this article, the antimicrobial and antiviral behaviors of Ag and Cu nanoparticles (NPs) are well known, and possible mechanisms for their actions, such as released ions, reactive oxygen species (ROS), contact killing, the immunostimulatory effect, and others have been proposed.
References
More filters
Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
Related Papers (5)
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria
Ivan Sondi,Branka Salopek-Sondi +1 more