Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
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TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
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Journal ArticleDOI
Silver nanoparticles induced accumulation of reactive oxygen species and alteration of antioxidant systems in the aquatic plant spirodela polyrhiza
Hongsheng Jiang,Hongsheng Jiang,Xiao-Ni Qiu,Xiao-Ni Qiu,Gen-Bao Li,Wei Li,Liyan Yin,Liyan Yin +7 more
TL;DR: Results clearly indicate that AgNPs are able to cause oxidative stress and affect the chloroplast structure and function of S. polyrhiza, and this effect was not caused by Ag(+) released from particles.
Journal ArticleDOI
Phytostimulation of poplars and Arabidopsis exposed to silver nanoparticles and Ag⁺ at sublethal concentrations.
Jing Wang,Yeonjong Koo,Anne K. Alexander,Yu Yang,Samantha Westerhof,Qingbo Zhang,Jerald L. Schnoor,Vicki L. Colvin,Janet Braam,Pedro J. J. Alvarez +9 more
TL;DR: The observed phytostimulatory effects preclude generalizations about the phytotoxicity of AgNPs and encourage further mechanistic research.
Journal ArticleDOI
Mechanistic Study of the Synergistic Antibacterial Activity of Combined Silver Nanoparticles and Common Antibiotics
Hua Deng,Danielle McShan,Ying Zhang,Sudarson Sekhar Sinha,Zikri Arslan,Paresh Chandra Ray,Hongtao Yu +6 more
TL;DR: In this paper, a combination of silver nanoparticles (AgNPs) and an antibiotic can synergistically inhibit bacterial growth, especially against the drug-resistant bacteria Salmonella typhimurium.
Journal ArticleDOI
Facile synthesis of novel size-controlled antibacterial hybrid spheres using silver nanoparticles loaded with poly-dopamine spheres
TL;DR: In this paper, a poly-dopamine sphere loaded with silver nanoparticles (Ag@PDS) was fabricated using a facile method, and the size of the uniform hybrid sphere is easily controlled by adjusting the ratio of ammonia to dopamine.
Journal ArticleDOI
Chemical Dissolution Pathways of MoS2 Nanosheets in Biological and Environmental Media.
Zhongying Wang,Annette von dem Bussche,Yang Qiu,Thomas M. Valentin,Kyle D. Gion,Agnes B. Kane,Robert H. Hurt +6 more
TL;DR: It is shown that MoS2 nanosheets are thermodynamically and kinetically unstable to O2-oxidation under ambient conditions in a variety of aqueous media, with important implications for biomedical applications and environmental risk.
References
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Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
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