Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
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TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
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Fabrication of silver-coated cobalt ferrite nanocomposite and the study of its antibacterial activity
TL;DR: In this paper, a new silver coated cobalt ferrite nanocomposite, Ag@CoFe2O4, was prepared by a two-step procedure using glycine as a fuel.
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An efficient antimicrobial depot for infectious site-targeted chemo-photothermal therapy
TL;DR: Combinational chemo-hyperthermia therapy of Ag+-GCS-PDA@GNRs could thoroughly ablate abscess and accelerate wound healing via a synergistic antibacterial effect with outstanding synergistic bacteria ablating.
Journal ArticleDOI
Detection, quantification and derivation of number size distribution of silver nanoparticles in antimicrobial consumer products
Claudia Cascio,Otmar Geiss,Fabio Franchini,Isaac Ojea-Jiménez,François Rossi,Douglas Gilliland,Luigi Calzolai +6 more
TL;DR: In this paper, an in-house developed method based on Asymmetric Flow Field Flow fractionation-Inductively Coupled Plasma Mass Spectrometry (AF4-ICP-MS) for the simultaneous detection and quantification of citrate-stabilised silver nanoparticles (AgNPs) in water, has been applied to realworld liquid antimicrobial consumer products based on colloidal silver.
Journal ArticleDOI
Sustainable Antibiofouling Properties of Thin Film Composite Forward Osmosis Membrane with Rechargeable Silver Nanoparticles Loading
Zhongyun Liu,Yunxia Hu +1 more
TL;DR: A simple and facile approach has been developed to in situ generate silver nanoparticles (Ag NPs) on the thin film composite forward osmosis (TFC FO) membrane for sustainable antibiofouling performances.
Journal ArticleDOI
Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine
Emilio I. Alarcon,Branka Vulesevic,A Argawal,Alex Ross,P Bejjani,James Podrebarac,Ranjithkumar Ravichandran,Jaywant Phopase,Erik J. Suuronen,May Griffith +9 more
TL;DR: A new strategy to pre-stabilize and incorporate AgNPs with different colours into collagen matrices for fabrication of corneal implants and lenses is reported, and their in vitro and in vivo activity is assessed.
References
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Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
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