Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
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TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
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Journal ArticleDOI
Antibacterial properties of silver dendrite decorated silicon nanowires
Hashim Alhmoud,Bahman Delalat,Xavier Cetó,Roey Elnathan,Alex Cavallaro,Krasimir Vasilev,Nicolas H. Voelcker +6 more
TL;DR: The results demonstrate that the antibacterial action of silicon nanowires generated by via metal-assisted chemical etching (MACE) against Escherichia coli and Staphylococcus aureus bacteria strains can be attributed to the layer of silver dendrites found on the surface of the SiNWs as a natural by-product of the MACE reaction, thus eliminating the need for a second surface modification step with an antibacterial agent.
Journal ArticleDOI
Novel Imaging of Silver Nanoparticle Uptake by a Unicellular Alga and Trophic Transfer to Daphnia magna.
Neng Yan,Wen-Xiong Wang +1 more
TL;DR: In this paper, the authors demonstrate that AgNPs were internalized in a freshwater phytoplankton species Chlamydomonas reinhardtii, but the entrance pathways varied with their surface coatings.
Journal ArticleDOI
Dendritic Silica Particles with Well-Dispersed Ag Nanoparticles for Robust Antireflective and Antibacterial Nanocoatings on Polymeric Glass
TL;DR: In this paper, a series of single-particle-layered nanocoatings were prepared by partially embedding dendritic fibrous nanosilica (DFNS) with well-dispersed Ag nanoparticles (NPs) onto the surface of poly(methyl methacrylate) (PMMA) polymeric glass via organic vapor treatment.
Journal ArticleDOI
Antibacterial and Effective Air Filtration Membranes by “Green” Electrospinning and Citric Acid Crosslinking
Miaomiao Zhu,Dawei Hua,Ming Zhong,Lingfeng Zhang,Fang Wang,Buhong Gao,Ranhua Xiong,Chaobo Huang +7 more
TL;DR: In this paper, green electrospinning and thermal cross-linking was used to fabricate air filtration membranes via green electro-spinning, thermal crosslinking, and thermal co-connections.
Journal ArticleDOI
Combination analysis of the physiology and transcriptome provides insights into the mechanism of silver nanoparticles phytotoxicity
Chuan Ling Zhang,Hong Sheng Jiang,Shu Ping Gu,Xiao Hao Zhou,Zhen Wei Lu,Xiu Han Kang,Liyan Yin,Jiaquan Huang +7 more
TL;DR: More than the released Ag+, nanoparticle-specific effects are responsible for the toxicity of AgNPs in Arabidopsis thaliana.
References
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Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
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